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By Patrick Wingrove (Reuters) -Moderna and rival Pfizer on Wednesday said their updated COVID-19 vaccines generated strong responses in testing

Japan-based Astellas Pharma on Wednesday withdrew a lawsuit filed against the U.S. government, days after its prostate cancer

A grandmother who contracted sepsis which made her hallucinate, have “blotchy skin” and turn the “colour of stone” later found out that her four-year-old grandson had the condition and Strep A at the same time as her, with the pair being “lucky to be alive”. Lorna Conaghan, 63, a retired business control analyst from Gourock, Scotland, and her grandson, Alfie Crawford, four, had sepsis at the same time, and Lorna “just couldn’t believe it”. In September 2022, Lorna was due to have a shoulder replacement, but on the morning of the surgery, she “did not feel right” and felt “on edge and weak” – but put it down to nerves. Little did she know this was her first warning sign of sepsis. After informing the doctors, they soon realised that one of her organs was infected and she was admitted to the hospital’s high dependency unit. The following day, Lorna was diagnosed with sepsis as her skin began to look mottled, and doctors told her that she “would have been dead” if it was caught any later. After having antibiotics and a few more hospital visits, Lorna began to recover, but it has taken her 11 months to “go back to normal” and have regulated blood pressure. When Lorna was in hospital, her grandson Alfie, who was three at the time, had chicken pox and a cold, which developed into sepsis and Strep A. Lorna thinks that because Alfie’s mum knew about her symptoms of sepsis, it helped her realise something was wrong. Alfie’s lungs were “full of pus”, so he was put on a ventilator and was in an induced coma for over a week. He also had to “learn to walk again”, and slowly has been able to make a full recovery – with Lorna saying the family are “so lucky to still have him”. Lorna told PA Real Life: “Alfie got sick when I was in hospital, and when I found out I just couldn’t believe it. “I think me having sepsis made Alfie’s mum realise that he had more than just a cold and chicken pox. “We’re both so lucky to still be here and that Alfie is back to running around and having balls of energy.” On July 4 2022, Lorna broke her arm after slipping on her dog’s tennis ball and ended up needing a shoulder replacement. On the day of the surgery, September 30 2022, at Inverclyde Royal Hospital, Greenock, she began to “not feel right” but put it down to nerves. She said: “I told the doctors and they tested me for Covid, but I was negative, and after a few more tests they thought one of my organs might be infected. “They thought it was my heart to begin with, but they couldn’t figure out what organ it was. “The biochemist worked out which antibiotic would best kill the infection, so I was put on that straight away.” Lorna stayed in the hospital for nine days, with seven of them being on the high dependency unit. She said: “They thought it was my kidneys, so they were trying to get them functioning again. “With hindsight, it was terrifying, but I didn’t realise how serious it was at the time. “I was a strange colour, the colour of stone, and I was all blotchy. “Doctors said if they caught it much later, or if I wasn’t in hospital, I would have been dead.” Four weeks later, Lorna was admitted to the high dependency unit again after her GP noticed she had extremely low blood pressure and low heart rate. She said: “I was so confused – when family members would visit me, I’d ask them to leave because I was hallucinating and didn’t want them to see me like that. “I thought there was a castle outside the hospital – I thought I was seeing it outside my window, and I remember thinking that we’ll have to go there once I’m out of hospital.” Since then, it has taken Lorna 11 months to get “back to normal” and her blood pressure regulated. She said: “I’m still having problems with my liver, but now I’m just tired. It’s really taken it out of me. I can only take the dog so far, I’m just so tired all the time.” While Lorna was in hospital, Alfie’s mum informed her that he was feeling unwell. Stephanie did not want to worry Lorna when she was already sick, but it turned out that Alfie, who was three at the time, had also contracted sepsis. Lorna said: “He came home from nursery with chicken pox, and also had a bit of a cold. “Then it just got worse – he was having terrible pains in his back, and I think Stephanie had just listened to what I had said about my symptoms, and it made her realise subconsciously that he might be more unwell than he is coming across. “They called the paramedics, and that night he got a lot worse – when they arrived at A&E, she took him up to the desk and said, ‘We’re going to have a dead child if we don’t do something’.” Within half an hour, Alfie was admitted to intensive care at Glasgow Children’s Hospital and doctors soon realised his lungs were “full of pus” and that he had sepsis, which had turned into Strep A. So, Alfie was put on a ventilator and was in an induced coma for over a week. “Doctors made it clear to Alfie’s family that it was indeed life-threatening and that he was very lucky to be alive Lorna Conaghan Lorna said: “He had to learn to walk again – he was so weak after he woke up. “Doctors made it clear to Alfie’s family that it was indeed life-threatening and that he was very lucky to be alive. “His legs were so weak – he hadn’t eaten much while being poorly.” After having antibiotics and being in the induced coma, Alfie is now “running around”. Lorna said: “With me, I’ve had a good life, but it was so unfair to think that little Alfie could have died – he hasn’t had a life yet. “We’re just so lucky to still have him with us. “This whole experience has made me appreciate everything – when I take the dog for a walk I have a sit down on the bench and take in all the lovely scenery. “I have treated every day since Alfie and I got better as a bonus day in my life.” Read More Amy Dowden reveals ‘life-threatening’ sepsis diagnosis amid cancer treatment BBC Radio 2’s Tony Blackburn reveals he had sepsis and pneumonia in health update Martha Mills: Parents of girl who died after NHS mistakes call for new right to get second opinion Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live

A father-of-three who was told he looked like “Casper the ghost” before being diagnosed with acute myeloid leukaemia (AML) and given three weeks to live, meaning he has planned his own Requiem Mass and funeral, has defied doctors’ expectations by outliving his prognosis by more than a year and said he is going to “keep fighting”. Dennis Blackman, 62, a former chartered building surveyor and carer who lives in Eltham, London, said he has always been active – playing rugby, lifting weights, and going to the gym at least three times a week. However this all changed when he suffered an unexpected stroke in 2015. His health deteriorated over the following years, he had a hip replacement at 58, and after experiencing symptoms of extreme exhaustion, cold hands, and muscle weakness in early 2022, his wife Sally, 62, a former flooring showroom manager, suggested he book a doctor’s appointment. After weeks of blood tests and blood transfusions in hospital and being told he looked like “Casper the ghost” because he was so pale, he underwent a bone marrow biopsy, and this led to the devastating news in March 2022 that he has AML – a type of blood cancer – and three weeks to live. Dennis told PA Real Life: “I just broke down and I had this unbelievable feeling of guilt because I said to the consultant: ‘What have I done wrong? How do I tell my children and wife?’ “It’s a huge burden to put on someone, to tell them that you’re dying and it’s going to be very quick. “We had many dark days, and every time I looked into my children’s eyes I just burst into tears… it was a very emotional period for all of us.” Dennis, who has lost 50kg (7st 9lbs) since his diagnosis, did not start chemotherapy until months later due to him being too weak, and in January 2023, he was told the chemotherapy was “not working any more”. From that point on, he said he wanted to “enjoy each day” rather than pursuing more aggressive forms of treatment – and since then, he has planned his own Requiem Mass with hymns such as How Great Thou Art and Ave Maria (As I Kneel Before You), as well as the arrangements for his funeral. Now, Dennis continues to drive, go shopping, and enjoy time with his family, and he said he is going to “keep fighting” during the time he has left as “you only have one life”. “Every day you go to bed and you think: ‘Am I going to wake up tomorrow?’ And then each morning you think: ‘Is it going to be today that I’m going to die?’” Dennis explained. “It was extremely difficult in the beginning and I tried to shut the world out… but as time went on, I realised you can’t live like this forever. “You only get one life, so I’m going to do everything I can to keep fighting.” During his 40s and early 50s, Dennis said he enjoyed going out for meals with his wife Sally, playing rugby with his sons James, 37, and Joe, 31, and keeping fit by going to the gym several times a week. He foresaw spending his days in retirement with his family, out in the garden, or fishing, but he said this all changed when he had a stroke in 2015, aged 54, and his health declined from then on. In early 2022, he spent six weeks at Queen Elizabeth Hospital in London after noticing some unusual symptoms and was told: “You look like Casper (the ghost), you’re very anaemic.” He then underwent several blood tests and blood transfusions, and although he had “an idea” that he may have cancer, he said he could never have prepared himself for his diagnosis on March 31 2022. “About one o’clock, I had a knock at the door and I thought: ‘That’s ominous’,” Dennis said. “The consultant and the specialist nurse came in and they said: ‘Unfortunately it’s bad news, you’ve got severe AML and there’s not a lot we can do at this stage.’ “’You’ve got three weeks to live, and I’d advise you to go home and tell your wife and family, and make sure everything’s in order because you haven’t got long left’.” Given Dennis has severe neutropenia as well – a low number of white blood cells – he is at a higher risk of contracting serious infections, and this meant he missed several family celebrations in the months that followed, including his grandson’s birthday party and stepdaughter’s wedding. He developed multiple chest infections and fevers and was not deemed fit enough to start chemotherapy straight away, and he ended up spending three months in hospital from July to October. “We thought we were going to lose him, he was so ill,” Sally, who has been married to Dennis for 10 years, explained. “Even the consultant thought we were going to lose him. “I was scared because I just thought: ‘How can this be happening when we’ve only just met each other?’ We just thought we were going to have the rest of our lives together.” However, Dennis, who is Catholic, said he “fought and prayed every day”, adding: “I said to the consultant: ‘If you promise to me you won’t give up on me medically, I promise I’ll fight this all the way.’” Dennis was determined to get better and, with the help of a physiotherapist, he built up his strength – and at one point, he was walking 10,000 steps a day along the hospital corridor. Towards the end of October 2022, Dennis said “everything seemed hunky dory” and he commenced the first of four rounds of chemotherapy, where he experienced nausea, exhaustion, and “tremendous leg bone pain”. By January, he was told the chemotherapy was “not working”, but rather than trying other forms of treatment, he said he wanted to “enjoy the little things” and the time he has left. He has planned his own Requiem Mass and funeral to relieve any pressure from his family, but also to give him “strength” and some control over his destiny – and aside from his regular check-ups and blood tests each week, he is setting himself small milestones, such as attending a Madness concert at the O2 in December. Although he is “struggling to survive”, he said he would do “anything to get another day” – and that is why he is holding onto hope and wants to encourage others never to give up. “Even though I pray every day, not once have I asked God to take it away from me – all I ask is that He’s with me when I need him, to give me the strength to carry on fighting,” he said. “Leukaemia is painful and every day I question whether I’ll see another day, but we just try and keep going and I hope that my story gives hope to others. “I’ve still got lots of memories to make yet, so I’m going to fight this all the way.” For more information and support, visit Leukaemia Care’s website at leukaemiacare.org.uk Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live One in 10 ‘spending beyond their means’ – try these 7 cutbacks guaranteed to save families money What is combination cholesterol therapy, as study suggests it could save lives? Cancer cases in young people ‘are rising’ – the warning signs to look out for

Fulton County Superior Court Judge Scott McAfee, who is presiding over the Georgia election subversion case against former President Donald Trump and 18 other co-defendants, will hold his first hearing Wednesday afternoon amid questions of how soon a trial could begin.

Seal has spoken about his close relationship with his and his ex-wife Heidi Klum’s 19-year-old daughter, Leni Olum Klum. The musician, 60, took to Instagram on 4 September to share a snap of him and his daughter in New York City together. In the caption, he described how Leni has ultimately shaped his life, and pointed out how grateful he was for her. “In NY with the young woman who changed my life for the better 19yrs ago. Thank you Leni for making me a better person,” he wrote, before signing the tribute with: “Love you, - papa.” In the comments, Leni expressed her love for her father’s post, writing: “So cute! I love you papa,” along with a red heart emoji. Many fans of the singer went to the comments to praise his sweet relationship with Leni. “So much love in this photo! Have a wonderful time together!” one wrote, while another added: “Daddy and Daughter. Beautiful!!” The young model was born in May 2004, right after Klum split from Leni’s biological father, Italian businessman Flavio Briatore. In December 2009, Seal legally adopted Leni when she was five years old, while the singer and supermodel were still married. The former couple went on to have three more children: sons Henry, 17, and Johan, 16; and daughter Lou, 13. Klum filed for divorce in April 2012. This isn’t the first time that Seal has shown his support for the 19-year-old. During an interview with E! News in March, he spoke out about Leni’s career, as she has followed in her mother’s footsteps by becoming a model. While he noted that he’s “so proud of everything that Leni has done”, he’s “more proud of everything that she is”. “She walks through life with this type of humility that allows her to move so gracefully through it all and she has an innate understanding of people in general and people’s feelings,” the singer explained. “So I’m kind of more impressed with everything that she is.” Seal - whose real name is Seal Henry Olusegun Olumide Adeola Samuel - also spoke candidly about co-parenting with his ex-wife, adding: “I’d like to think, as a parent, that we have - between her mother and myself - that we’ve instilled some of that in her. But she can do no wrong in my eyes and she’s quite wonderful.” Earlier this year, Klum applauded her daughter for working on her mode;ling career while studying in college. “I’m very proud of my daughter and her modelling. And she’s studying at the same time, she’s juggling already,” the America’s Got Talent judge said during an interview with People in March. Meanwhile, Leni has also spoken out about working in the modelling industry as the child of two famous parents. During an interview with People in October 2022, she acknowledged that she “got a lift into” the modelling world due to her upbringing. “It’s just a fact. My parents are famous,” she said. However, when she was asked about the infamous “nepotism baby” label given to children of celebrities, Leni said it’s her own work ethic that has helped build her career thus far. “I did get help starting off, and I know that people would dream to start off with what I had,” the college student explained. “I’m so grateful that I’ve been able to take what was gifted to me by my mom. But I am doing the work and putting in the time. Now I’m working on my own, travelling alone, going to school. My mom and I just have the same love for the same thing.” Although she said that her own ambition has led her to success in her career, she still credited her parents for instilling a strong work ethic in her at a young age. “They have both taught me to be myself, and to do what makes me feel comfortable,” she said. “You can tell if you’re not comfortable and then the best of you isn’t brought out. I just think you should be open and honest with what makes you comfortable, be yourself, do what you love.” Read More Heidi Klum opens up about her and husband Tom Kaulitz’s 16-year age gap Heidi Klum’s model daughter Leni shows off grisly burn after admitting she ‘didn’t use enough sunscreen’ Heidi Klum gushes with pride over daughter Leni for ‘juggling’ modelling and college Heidi Klum denies she counts calories after report she eats 900 calories a day Sleeping pill could reduce levels of Alzheimer’s proteins Marathon runners on why autumn is the best time to start running

Gardaí say Commissioner Drew Harris is to attend a series of meetings as part of an ongoing operation.

When the late singer Jimmy Buffett was diagnosed with a rare skin cancer about four years ago, his younger sister Laurie Buffett McGuane was diagnosed with pancreatic cancer not long after.

Senate Republican Leader Mitch McConnell's office released an update about the 81-year-old Kentuckian's health after he froze in front of cameras last week for the second time in as many months.

Anthea Turner refuses to spend a fortune on skincare and instead just keeps a small collection of products for her complexion.

The 10-year-old climbed on to a tree after his family's car was swept into a river by deadly floods.

By David Randall NEW YORK U.S. stock fund flows into and out of the healthcare sector have swung