List of All Articles with Tag 'and'

The viral gaming hit Only Up has been surprisingly removed from gaming platform Steam with the creator of the title citing "stress" as the reason. Only Up became a big hit with gamers on various streaming platforms earlier this year with players attempting to complete the seemingly easily but hard-to-master platformer which involved a character scaling various objects higher and higher into the sky. However, the game has now been pulled from Steam's storefront so it's creator who goes by the alias of SCKR Games can focus on their next title, which according to IGN has a codename of Kilth. In a statement, SCKR Games said that Only Up is "a game I did for creativity, to test myself, and where I made a lot of mistakes." They added: "The game has kept me under a lot of stress all these months. Now I want to put the game behind me." "What I need now is peace of mind and healing. I plan to take a pause, and continue my education in game design and further with new experience and knowledge to direct my energies to my next game with the working title ‘Kith’ — it will be a new experience and a new concept with realism, a completely different genre and setting, and the emphasis is on cinematography. “This time I hope the project will be created by a small team. This is a challenging project on which I want to significantly improve my skills in game design.” The game had been removed from Steam back in June and later returned in July after copyrighted assets from another developer managed to get into the game but was soon resolved. It's unknown whether the game will return to Steam at a later date but its page remains available on the website although it cannot be purchased. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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For decades, sexual assault accusations marred his career - and for decades, the media failed to investigate.

Scientists have grown human kidneys in pigs, for the very first time. Researchers at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences and Wuyi University created human-pig chimeric embryos containing a combination of human and pig cells. When they transferred into 13 surrogate pig mothers, they developed kidneys that contained mostly human cells at a rate of 50 to 60 per cent, giving hope for potential transplants in the future. “Rat organs have been produced in mice, and mouse organs have been produced in rats, but previous attempts to grow human organs in pigs have not succeeded,” said the senior author Liangxue Lai. “Our approach improves the integration of human cells into recipient tissues and allows us to grow human organs in pigs.” The kidneys were not entirely human as they included vasculature and nerves made mostly from pig cells, meaning they could not be used for transplantation in their current form, but it is still a pretty impressive step. And apart from the kidneys, the embryos were dominated by pig cells, with very few human cells in the brain or central nervous system. Making brains using human and pig cells is very controversial for ethical reasons, so there are tight regulations for this kind of research. Meanwhile, pig cells tend to outcompete human cells during development, so previous experiments have created embryos that are almost entirely pig. The latest work, published in Cell Stem Cell, overcame this by genetically engineering a single-cell pig embryo so that it lacked two genes needed for kidney development. This created a gap within the embryo that could be filled by human cells. “We found that if you create a niche in the pig embryo, then the human cells naturally go into these spaces,” said Prof Zhen Dai of Guangzhou Institutes of Biomedicine and Health, another senior author. The scientists said that being able to incubate a fully human kidney inside a pig would be likely to take many years. “We would probably need to engineer the pigs in a much more complex way and that also brings some additional challenges,” said Miguel Esteban, also of the Guangzhou institute and a senior author. A central challenge would be to allow human nerves and vasculature to develop within the target organ without nerve cells developing in the central nervous system that could lead to a humanised brain. “Even theoretically it’s not clear how you’d do that,” said Ilic. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Everyone has a theory about their dreams and the science or meaning behind them. And when the weather hots up, the more bizarre they tend to get. “Dreams are a fascinating and enigmatic phenomenon that occur during sleep, encompassing a vast realm of imaginative experiences,” says sleep expert and CEO of MattressNextDay, Martin Seeley. “They are a collection of thoughts, images, sensations, and emotions that unfold within the theatre of our minds.” Why do we dream? When we sleep, our brain enters a complex state where it engages in various cognitive processes, explains Seeley, including memory consolidation, problem-solving and emotional regulation. “Dreams are thought to emerge from these processes, weaving together fragments of memories, desires, fears, and subconscious thoughts into a narrative or non-linear sequence,” adds Seeley. “And they can be surreal, vivid, or mundane, blurring the boundaries between reality and fantasy.” While the precise purpose and meaning of dreams remains a subject of exploration and debate, Seeley says they can serve as a portal into the inner workings of our minds: “Providing a canvas for exploration, processing of emotions, and glimpses into the subconscious depths of our psyche.” Why do we dream more when it’s hot? Lisa Artis, deputy CEO of The Sleep Charity, says: “When the weather is hot, it can disrupt our sleeping patterns, making it difficult to fall asleep in the first place – and causes us to wake more often during the REM (rapid eye movement) sleep phase.” REM sleep is where we experience intense dreaming, explains Artis – so waking during or at the end of this cycle can mean we are more likely to remember our dreams. “Dreams happen regularly, but are often forgotten and our mind’s way of unpacking the day’s events, dealing with stress and sorting through our day-to-day thoughts,” notes Artis. Our body heat generally peaks in the afternoon then starts to drop over an evening to prepare us for sleep, says Artis. Melatonin, the sleep hormone, is produced when this happens.“An ideal temperature is around 16-18°C and anything around the 24°C mark can cause restlessness,” says Artis. “So, it’s no surprise that when we’re experiencing a heatwave with temperatures reaching over 30°C, it affects our sleep.”Can a heatwave really make dreams more surreal? The connection between heatwaves and the content or nature of dreams is not fully understood. However, there may be a few possible explanations if your dreams seem weirder when the weather heats up – although Seeley points out these are all speculative. First off, he agrees it may have a lot to do with the fact we’re less comfortable and waking more when it’s hot. “These frequent awakenings can interrupt the normal sleep cycle and result in a higher probability of remembering dreams, including the more unusual or vivid ones,” he notes. “So, during a heatwave, the increased frequency of waking up during the night might contribute to a greater recall of strange or funky dreams.” Secondly, the body’s physiological response to heat may influence brain activity, he adds: “Heat can affect neurotransmitter levels, such as serotonin and dopamine, which play a role in regulating mood and emotions. These alterations in neurotransmitter activity might impact the content and emotional tone of dreams, potentially leading to more surreal or bizarre experiences.” Psychological factors could also play a role. Heatwaves can cause restlessness and increased stress levels in some individuals. Seeley adds: “Stress and emotional fluctuations can manifest in dreams as strange or unusual scenarios, as the mind processes and attempts to make sense of these experiences.” Can we stop strange heatwave dreams happening? While it’s probably not possible to completely control the content of our dreams, there are certain strategies you can try to promote better sleep – and potentially reduce the likelihood of experiencing a restless night and unusual dreams during hot weather. Create a cool sleep environment: “Use fans, air conditioning, or open windows to circulate cool air in your bedroom – and consider using lightweight, breathable bedding materials,” says Seeley. Stay hydrated: “Drink enough water throughout the day to prevent dehydration, especially during hot weather,” he continues. “Being adequately hydrated can help maintain a balanced sleep cycle.” Practice relaxation techniques: “Engage in activities that promote relaxation before bed, such as deep breathing exercises, meditation, or taking a warm bath,” suggests Seeley. “These practices can help calm your mind and promote a more restful sleep.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live What are the royals doing to mark the anniversary of the Queen’s death All the times Kate has channelled the late Queen’s style since her death YouTube begins verifying videos by UK doctors to tackle health misinformation

As Covid cases spread in 2020, visitors to the University of Arkansas for Medical Sciences were greeted by a colorful sign put up by grateful neighbors outside the university's medical center: "Heroes Work Here."

A row over pay and conditions has led to walkouts at two liquefied natural gas facilities.

Scientists in Israel have created a model of a human embryo from stem cells, without using sperm, eggs or a womb. A team at Israel's Weizmann Institute of Science made the model, which resembles an embryo at day 14, when it acquires internal structures but before it lays down the foundations for body organs, and the work was published in the journal Nature. But the scientists involved said it would take a long time yet to create an embryo from scratch. Team leader Jacob Hanna said the team took stem cells derived from adult human skin cells, as well as others cultured in the lab, then reverted the cells to an early state.They then manipulated them to make a model of an embryo, rather than an actual or synthetic one. "The question is, when does an embryo model become considered an embryo? When that happens, we know the regulations. At the moment we are really, really far off from that point," Hanna said. However, they said the work could open the door to new ways to test the effect of drugs on pregnancies, better understand miscarriages and genetic diseases, and maybe grow transplant tissues and organs. "They are not identical. There are differences from human embryos, but still, this is the first time, if you open an atlas or a textbook, you can say - yeah I can really see the similarity between them," said Hanna. "In about 1 percent of the aggregates we can see that the cells start differentiating correctly, migrating and sorting themselves into the correct structure, and the farthest we could get is day 14 in human embryo development," he said. Their next goal, Hanna said, is to advance to day 21 and also reach a threshold of a 50 per cent success rate. Magdalena Żernicka-Goetz, a professor of development and stem cells at the University of Cambridge, said the study joins six other similar human embryo-like models published from teams around the world this year, including from her lab. "None of these models fully recapitulate natural human development but each adds to ways in which many aspects of human development can now be studied experimentally," she said. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Everyone has a theory about their dreams and the science or meaning behind them. And when the weather hots up, the more bizarre they tend to get. “Dreams are a fascinating and enigmatic phenomenon that occur during sleep, encompassing a vast realm of imaginative experiences,” says sleep expert and CEO of MattressNextDay, Martin Seeley. “They are a collection of thoughts, images, sensations, and emotions that unfold within the theatre of our minds.” Why do we dream? When we sleep, our brain enters a complex state where it engages in various cognitive processes, explains Seeley, including memory consolidation, problem-solving and emotional regulation. “Dreams are thought to emerge from these processes, weaving together fragments of memories, desires, fears, and subconscious thoughts into a narrative or non-linear sequence,” adds Seeley. “And they can be surreal, vivid, or mundane, blurring the boundaries between reality and fantasy.” While the precise purpose and meaning of dreams remains a subject of exploration and debate, Seeley says they can serve as a portal into the inner workings of our minds: “Providing a canvas for exploration, processing of emotions, and glimpses into the subconscious depths of our psyche.” Why do we dream more when it’s hot? Lisa Artis, deputy CEO of The Sleep Charity, says: “When the weather is hot, it can disrupt our sleeping patterns, making it difficult to fall asleep in the first place – and causes us to wake more often during the REM (rapid eye movement) sleep phase.” REM sleep is where we experience intense dreaming, explains Artis – so waking during or at the end of this cycle can mean we are more likely to remember our dreams. “Dreams happen regularly, but are often forgotten and our mind’s way of unpacking the day’s events, dealing with stress and sorting through our day-to-day thoughts,” notes Artis. Our body heat generally peaks in the afternoon then starts to drop over an evening to prepare us for sleep, says Artis. Melatonin, the sleep hormone, is produced when this happens.“An ideal temperature is around 16-18°C and anything around the 24°C mark can cause restlessness,” says Artis. “So, it’s no surprise that when we’re experiencing a heatwave with temperatures reaching over 30°C, it affects our sleep.”Can a heatwave really make dreams more surreal? The connection between heatwaves and the content or nature of dreams is not fully understood. However, there may be a few possible explanations if your dreams seem weirder when the weather heats up – although Seeley points out these are all speculative. First off, he agrees it may have a lot to do with the fact we’re less comfortable and waking more when it’s hot. “These frequent awakenings can interrupt the normal sleep cycle and result in a higher probability of remembering dreams, including the more unusual or vivid ones,” he notes. “So, during a heatwave, the increased frequency of waking up during the night might contribute to a greater recall of strange or funky dreams.” Secondly, the body’s physiological response to heat may influence brain activity, he adds: “Heat can affect neurotransmitter levels, such as serotonin and dopamine, which play a role in regulating mood and emotions. These alterations in neurotransmitter activity might impact the content and emotional tone of dreams, potentially leading to more surreal or bizarre experiences.” Psychological factors could also play a role. Heatwaves can cause restlessness and increased stress levels in some individuals. Seeley adds: “Stress and emotional fluctuations can manifest in dreams as strange or unusual scenarios, as the mind processes and attempts to make sense of these experiences.” Can we stop strange heatwave dreams happening? While it’s probably not possible to completely control the content of our dreams, there are certain strategies you can try to promote better sleep – and potentially reduce the likelihood of experiencing a restless night and unusual dreams during hot weather. Create a cool sleep environment: “Use fans, air conditioning, or open windows to circulate cool air in your bedroom – and consider using lightweight, breathable bedding materials,” says Seeley. Stay hydrated: “Drink enough water throughout the day to prevent dehydration, especially during hot weather,” he continues. “Being adequately hydrated can help maintain a balanced sleep cycle.” Practice relaxation techniques: “Engage in activities that promote relaxation before bed, such as deep breathing exercises, meditation, or taking a warm bath,” suggests Seeley. “These practices can help calm your mind and promote a more restful sleep.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live All the times Kate has channelled the late Queen’s style since her death It’s not just dry skin: 5 things everyone needs to know about eczema YouTube begins verifying videos by UK doctors to tackle health misinformation

The remains of 2,000-year-old Roman walls have been discovered by archaeologist in Switzerland in the foothills of the Alps. During the excavation of a gravel pit in Cham in the canton, or state, of Aug in central Switzerland, the walls, which once protected a Roman building complex, were found. Other pieces have also been unearthed by archaeologists, include a plaster wall, iron nails, and gold fragments. As well as items such as bowls, millstones for grinding, glassware, and crockery and ceramic jugs known as amphorae. In a statement form the Office for the Preservation of Monuments and Archeology, the findings were labelled an "archaeological sensation" for the region and could shed light on Roman activity in central Switzerland. Gishan Schaeren, head of the Department of Prehistory and Protohistoric Archaeology said in the statement: "Roman buildings of similar dimensions were last excavated in Cham-Heiligkreuz almost 100 years ago. We were also amazed that the top bricks were even visible above ground." The walls extend over an area of at least 5,300 square feet (500 square metres). Although it's unclear how Romans used the site, including whether it was a "villa with a view or a temple building," said professor of archaeology of the Roman provinces at the University of Bern Christa Ebnöther. The team said that findings of Roman tableware known as terra sigillata - which means "sealed earth" in Latin - were found, suggesting elite people were at the site. The amphorae, which typically held liquids such as wine, olive oil and fish sauce, are evidence that Romans in the region traded with those in the Mediterranean. Archaeologists also found several copper and bronze coins, including a silver denarius minted by Julius Caesar from the first century B.C. The discovery of the Roman walls is not the first ancient find in the area. Previously, archaeologists had found remains of a middle Bronze Age settlement, burials from the late Bronze Age, and a number of coins form the era of the Celts. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

With September often thought of as a second January, it’s the perfect time to set goals and form new habits. Meal prepping is a great way to help you stay on track and reach your goals. Benefits include helping you to stick to healthier foods, saving money, minimising food waste, saving time and reducing stress. Sophie Dillon, head of nutrition at Fresh Fitness Food, has put together a few nutritious recipes (breakfast, lunch and dinner) that take less than 30 minutes to prepare and cook. Yoghurt and granola with berries Greek yoghurt is a great source of protein, and can also be beneficial for your gut, as it is a food-sourced probiotic (so long as it’s labelled to contain live cultures), and this homemade granola recipe is packed with slow-release carbs, providing a sustained energy release for your morning, and to help keep your blood sugar levels more stable. Tip: Batch-cook your granola and store in an airtight container for ease and an on-demand, nutritious addition to your yoghurts, smoothies, or if you just fancy a simple carby snack. Serves: 2 Time: 25 mins the first time, 5 mins once you have the granola on hand Ingredients: Handful of berries of your choice ½ cup ricotta cheese ½ cup Greek yoghurt ½ vanilla pod 1 scoop of vanilla whey For the granola: 50g buckwheat groats 100g oats 20g maple syrup 5ml olive oil ½ tsp ground ginger Method: 1. Blend the ricotta cheese till smooth and then mix in the Greek yoghurt, vanilla pod and whey protein. 2. Preheat the oven to 170C. 3. Place all ingredients for the granola into a bowl and thoroughly mix together. 4. Line a baking tray with some grease-proof paper, pour the granola mix onto the tray and pop in the oven for 10 minutes. 5. After 10 minutes, remove the tray and mix around the granola to break up any large clumps. 6. Place back into the oven for a further 10 minutes, then take out to cool. 7. Place the yoghurt in a bowl and top with granola and the berries of your choice. Bang bang chicken stir-fry Quick, easy meals are key when it comes to nailing your fitness goals, and this stir-fry is an easy lunchtime winner. We’d recommend cooking an extra couple of portions and popping them in the freezer for an easy dinner on busy days. Tip: If you end up with extra chicken, put it to the side to have in a bang-bang chicken salad. Serves: 2 Time: 15 mins Ingredients: 2 chicken breasts, cut into strips ½ juice of a lime 1 tbsp peanut butter ½ tsp tamari sauce ½ tbsp sriracha ½ carrot, julienne or grated ½ red pepper, sliced 1 spring onion, sliced 1 tbsp oil of choice (we recommend sesame for a nice, nutty flavour) 3 nests rice noodles ½ tbsp sesame seeds (optional) ½ red chilli, sliced and de-seeded (optional) Method: 1. Mix together the sriracha, lime, salt, lime, peanut butter and tamari thoroughly with a whisk. 2. Mix all ingredients together so the chicken is well coated 3. Heat the sesame oil in a wok. Once hot, add the chicken to the pan, and cook until golden. 4. While the chicken is cooking, cook your noodles per the instructions on the packet, and leave to stand for one minute before adding to your pan. 5. At the same time, add your carrots and red pepper and stir until everything is coated in the sauce/oil mixture. 6. Once the chicken is cooked and the veg is soft, mix in your spring onions, and plate up. 7. Garnish with sesame seeds and chilli, if desired. Crispy tofu poke bowl Tofu is a great source of plant-based protein, containing all the essential amino acids your body needs. It’s also rich in vitamins and minerals, including calcium, iron and vitamin A. The great thing about crispy tofu, aside from its nutritional benefits, is that it works just as well in leftovers, too. Throw it in a tofu satay curry, pad thai or into a salad for a plant-based protein boost. Serves: 2 Time: 30 mins Ingredients: 1 block of firm tofu 1 tbsp olive oil ½ tsp smoked paprika 1 tsp cornflour ½ carrot 100g cucumber 50g edamame 50g peas 150g uncooked rice 100g tenderstem broccoli 1 tbsp sesame seeds (optional) 1 nori sheet, sliced into strips (optional) Salt to taste Method: 1. Drain the tofu and cut into equal-sized pieces. 2. Mix the tofu with cornflour, salt, olive oil, smoked paprika, and tofu together. 3. Roast on lined trays at 190C until brown and crispy – around 20 mins. Drain once cooked. 4. While the tofu is cooking, cook your rice as per the instructions. 5. In the meantime, prepare your veg. Chop and de-seed your cucumber. 6. Steam your tenderstem, peas and edamame. 7. Once your tofu is crispy and your rice is cooked and drained, plate everything up, and garnish with the nori and sesame seeds. Read More Is bottomless prosecco going to be killed off by climate change? Budget Bites: Three ways to pimp up university student classics Epicurus: American fast food meets the Middle East in Camden Market ‘How being thrifty in the kitchen helped me get on the housing ladder’ How to make spinach and mushroom quiche For a quick sugar fix, try this Biscoff microwave mug cake