Sepsis is an illness that affects nearly 50 million people worldwide each year, with around 11 million deaths attributed to the condition. In the United States, at least 1.7 million adults in the US develop sepsis annually, and nearly 270,000 die as a result, the Centres for Disease Control and Prevention (CDC) says. It affects 245,000 people in the UK each year, with around 48,000 deaths, according to the UK Sepsis Trust. World Sepsis Day commemorated on 13th September every year, strives to raise global awareness of the life-threatening condition. The day is seen as “an opportunity for people worldwide to unite in the fight against sepsis,” the Global Sepsis Alliance says. Here is everything you need to know about sepsis: What is sepsis? Sepsis Research says when the condition strikes, the immune system “overreacts” and begins to attack the infection and everything else around it “including the body’s own tissues and organs.” “Any type of infection — bacterial, viral or fungal — can lead to sepsis,” it adds. When sepsis occurs, it can cause inflammation and cause blood clotting around the body, if it does not get treated, it can result in death, organ failure and tissue damage, CDC says. Sepsis cannot be caught from another person, the NHS explains. What are the symptoms? The World Health Organisation (WHO) explains that the condition is a “medical emergency,” so if you think a person is exhibiting signs of sepsis or if you are showing signs – make sure you call 999 or go to the emergency room immediately. According to WHO, common signs and symptoms include: • Fever or low temperature and shivering • Confusion • Difficulty breathing • Clammy or sweaty skin • Extreme body pain or discomfort • High heart rate, weak pulse or low blood pressure • Low urine output Symptoms in children include: • Fast breathing • Convulsions • Pale skin • Lethargy • Difficulty waking up • Feeling cold to touch What are the causes? The Mayo Clinic says any type of infection can lead to sepsis and those that more commonly cause the condition include infections of: • Lungs, such as pneumonia • Kidney, bladder and other parts of the urinary system • Digestive system • Bloodstream • Catheter sites • Wounds or burns “Sepsis often presents as the clinical deterioration of common and preventable infections such as those of the respiratory, gastrointestinal and urinary tract, or of wounds and skin. Sepsis is frequently under-diagnosed at an early stage - when it still is potentially reversible,” the Global Sepsis Alliance says. Who is most at risk? The people most at risk of the condition, according to Mayo Clinic, are: • People with lower immune response, such as those being treated for cancer • People with human immunodeficiency virus (HIV). • People with chronic diseases such as diabetes kidney disease or chronic obstructive pulmonary disease (COPD). • people who are in intensive care or longer hospital stays. • People over the age of 65 • Infants How many cases are there globally? The WHO says a scientific publication estimated that in 2017 there were 48.9 million cases and 11 million sepsis-related deaths worldwide, which accounted for almost 20 per cent of all global deaths. That same year, almost half of all global sepsis cases occurred among children with an estimated 20 million cases and 2.9 million global deaths in children under 5 years of age. How can it be prevented? The Global Sepsis Alliance says the best to to avoid sepsis is by preventing infection. This can be done by undergoing vaccinations, ensuring that you only come into contact with clean water, washing your hands properly and if you are giving birth - making sure it is in a clean and sterilised environment. Can sepsis be treated? Sepsis can be treated with appropriate treatment such as antibiotics – this should be given as soon as possible. The CDC says sometimes “surgery is required to remove tissue damaged by the infection”. “Antibiotics are critical tools for treating life-threatening infections, like those that can lead to sepsis,” the CDC adds. Read More 5 things everyone needs to know about eczema 13 potential cancer symptoms you should get checked out How can I improve my teenager’s low mood? Duran Duran’s Andy Taylor says he’s ‘asymptomatic’ after end-of-life diagnosis Nine hours of parallel surgery: how Britain’s first womb transplant was carried out Bursts of activity that make you huff and puff ‘linked to reduced cancer risk’

Former New Jersey Gov. Chris Christie filed to run for president on Tuesday ahead of announcing his second bid for the White House and kicking off another clash with former President Donald Trump, the GOP frontrunner and a former Christie ally.

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A woman is furious at her mother for joking about her unborn baby's name. Posting on Reddit, she explained she has a tricky relationship with her mother and has been annoyed with how she's reacted to the pregnancy. "For example, when my husband and I announced the pregnancy, she used the pictures we posted but instead wrote a whole post about becoming a grandmother," she explained. "Literally nothing about being happy for my husband and I. She didn’t even tag us in it or mention us." But things went from bad to worse. Her husband and her chose an "old family name" that she decided not to share on the Reddit post that means a lot to them. But her mother began blasting our baby name everywhere," she said. She said that people would mock it in an exaggerated southern accent and got her friends to join in. The woman explained: "It seems innocuous enough - but she isn’t even born yet. I kind of wanted to be the one to A. introduce my baby to the world and announce her name that means a LOT to my husband and I and B. I have never once said to actually refer to her" how her Mum thinks it is pronounced. "I have been fairly mum on my own social media about what the baby’s name will be, and even amongst my own friends have only shared her name if they asked," she continued. When she raised the issue with her mother and she said she was just trying to be funny and has now given her the silent period. Chaos. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Nikki Alcaraz vanished without trace while on a roadtrip from her home in Tennessee to California with her boyfriend Tyler Stratton. Ms Alcaraz, 33, was last seen in the New Mexico town of Moriarty on 6 May. Authorities and her desperate family are appealing for information about her whereabouts. The missing person case has drawn comparisons to the Gabby Petito investigation after sheriff’s deputies in Torrance County pulled the couple over after receiving reports that Mr Stratton had assaulted Ms Alcaraz. The officers let them go without pressing criminal charges after Mr Stratton claimed he had also been hit. Here’s what we know about the case. The trip Nikki Alcaraz, a mother of two also known as Nikki Hernandez, left her home in Cheatham County, Tennessee, in her 2013 Jeep Wrangler with Tennessee plates in late April bound for Orange County, to visit family. Ms Alcaraz was travelling with her boyfriend Mr Stratton and a pet dog. On 4 May, sheriff’s deputies in Torrance County, New Mexico, pulled the couple over after receiving a report that he had struck Ms Alcaraz. Mr Stratton told authorities that he had also been hit, and both declined to press charges. Authorities have since released photos showing Ms Alcaraz with a black eye, cuts on her face and severe bruising on her arms after the alleged assault. “He beat her up pretty badly,” her brother Josh Alcaraz told Fox5. “A truck driver had to pull him off of her, call the police, the police picked him up, took him a couple exits down and dropped him off. She was diagnosed with a traumatic brain injury, and a broken hand or wrist.” Ms Alcaraz was taken to a Super 8 motel in the town of Moriarty. A friend travelled from California and stayed with her overnight at the motel. The plan was for the friend to take her back to California. On 6 May, Ms Alcaraz left the motel and told the friend she was going to try to find her boyfriend. This was the last time she has been seen alive, the woman’s family said. Her sister Toni Alcaraz told WKRN that she received a text on 8 May saying she was in Arizona, and planned to continue the trip to California. She hasn’t heard anything since then. Ms Alcaraz told the news site it was highly unusual not to hear from her for an extended period. Ms Alcaraz’s licence plate was picked up near Flagstaff, Arizona, on 9 May. But her phone has reportedly been switched off, and no further sightings have been reported. Missing person investigation Toni Alcaraz said she filed a missing persons report in New Mexico as that was where she was last seen. Josh Alcaraz said he feared that his sister’s vehicle might have broken down in the desert or come off the road. "We would like everybody to keep their eyes open, and if you see the Jeep, if you see him, if you see her, call somebody. Call the police," he told Fox5. Officials in Cheatham County, Tennessee, are working with law enforcement agencies in New Mexico and California to try to locate Ms Alcaraz. “Due to a history of domestic assault we believe she is in danger,” the Cheatham County Sheriff’s Office said in a Facebook post appealing for information. District Attorney General Ray Crouch told WKRN his office had requested a nationwide extradition for Mr Stratton, who is also missing. Mr Stratton is wanted on an unrelated arrest warrant for theft and begged for the public’s assistance. Family say they are holding onto the hope of finding Ms Alcaraz alive. “If you see the Jeep, if you see him, if you see her, call somebody,” Josh Alcaraz told Fox5. “Obviously, worst-case scenario is very present in the back of my mind. I’m trying to hold out hope.” Ms Alcaraz, who is also known as Nikki Cunningham, is 5’6” with brown eyes and black/brown hair. She also has several distinctive tattoos. Anyone with information about her whereabouts is asked to call police in Moriarty on 505-832-6060 or 505-834-2705. Mr Stratton’s family have reportedly not filed a missing person report, according to online reports. Gabby Petito comparisons The allegations of assault on a cross-country road trip have been drawing comparisons to the 2021 disappearance and murder of vlogger Gabby Petito. Petito set off from her home in New York in July that year with her boyfriend Brian Laundrie. The couple was pulled over in Utah by officers from the Moab Police Department on 12 August after receiving reports that Laundrie had struck Petito. They were allowed to continue separately after Laundrie claimed he had been hit by Petito. After a nationwide search and international media attention, Petito’s remains were found in the Grand Teton National Park in Wyoming in September. Laundrie later shot himself in the head and left a suicide note confessing to killing Petito. Petito’s family is suing the Moab Police Department for failing to follow the law and protect her during the traffic stop. An independent review of the domestic assault incident found the officers had made several mistakes, and should have been classified as a domestic assault. Petito’s family are also suing Laundrie’s parents Chris and Roberta for emotional distress. Read More Search for missing woman who vanished on cross-country roadtrip with her boyfriend sparks Gabby Petito comparisons Bombshell letter where Brian Laundrie’s mother vowed to ‘dispose of body’ is given to Gabby Petito’s parents Louisiana high school graduate who fell off boat in Bahamas is lost at sea as Coast Guard calls off search

Gen Brown would become the first black joint chiefs chairman in three decades, after Colin Powell.

Gregg Berhalter will return as head coach of the US Men's National Soccer Team, US Soccer announced Friday. His new contract will run through the conclusion of the 2026 FIFA World Cup, to be hosted jointly by the US, Canada and Mexico.