Josh Magennis is determined to keep proving his worth to Northern Ireland for as long as possible. When manager Michael O’Neill said after last month’s defeat to Kazakhstan he needed to evaluate some of the older players in his squad and whether they could still deliver for the team, the 33-year-old Magennis recognised he was among those under the spotlight. But a player who has 73 caps for Northern Ireland, having made his debut against Turkey in May 2010, still savours every opportunity to represent his country. “It’s up to me to stay fit, perform at club level and when I get a chance in matches here or in training show I’m still worth having around,” Magennis told the PA news agency. “I know I’m getting on but to me that’s just an excuse, whether people say it for you or you say it yourself. If you still play with intent, with the sports science that’s available now you can play endlessly. It’s up to you to prove you are worth your place in the squad.” Magennis went as far as telling fans at a meet-and-greet event in Belfast this week that he would fancy playing at Euro 2028 when it is hosted by the UK and Ireland in four and a half years’ time, when he would be just shy of 37. “Playing for your country is the biggest accolade you’ve ever had,” Magennis said. “I’m never going to retire and nor will I ever say I’ve retired. “If Michael decides, or anyone else decides, they don’t want me to come any more that’s up to them but I can never retire on my country. That’s not how I will be going out.” His love of playing shines through as he discusses his season so far with League One Wigan and “riding the wave” of being back after an injury lay-off. Magennis saw his 2022-23 campaign cut short by a bad knee injury in April, forcing him to miss Northern Ireland’s June fixtures as he went through a lengthy rehabilitation process. Although Magennis got himself back to fitness by August, the early season form of Charlie Wyke, who has scored six in 11 for Wigan, has meant all but two of his 10 club appearances have been from the bench, but one of them saw him score a hat-trick in an EFL Trophy win over Leicester Under-21s. “Charlie has been on fire and I’ve just had to wait for my chance,” Magennis said. “At any level scoring goals is massive. The goals don’t move. I’m just feeling good to be back and ready.” Goals would certainly not go amiss for a Northern Ireland side who have only scored four in their six Euro 2024 qualifiers to date, suffering four 1-0 defeats along the way. Qualification is beyond them but there is a clear opportunity to end a five-game losing streak when San Marino, the only team O’Neill’s side have beaten so far, visit Windsor Park on Saturday. But while they can change the mood with victory, Magennis said the team does not need a reset. “It’s not about trying to change our mentality,” he said. “Michael is working towards something. “I don’t want to say we’re rebuilding but there’s been an influx of new players, a lot of players Michael’s not been around before and a lot of players who are experiencing international football for the first time. “It’s just about trying to keep going, keep grafting and trying to implement what Michael wants us to do. It’s been tough not winning. This is a results-based business and everyone wants to win but there’s a process and Michael has proved this process has worked before. We’ve got to trust in it.” Read More Andy Farrell feels Ireland are becoming better at handling pressure Charlie Savage impresses Rob Page during his Wales debut Harry Maguire supported by ‘role model’ David Beckham after Hampden experience I want to play – Harry Maguire admits lack of matches will become an issue England forward Ollie Watkins: I no longer go shopping due to recognition Conor McGregor closes in on UFC return by re-entering anti-doping test programme

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Scientists have grown human kidneys in pigs, for the very first time. Researchers at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences and Wuyi University created human-pig chimeric embryos containing a combination of human and pig cells. When they transferred into 13 surrogate pig mothers, they developed kidneys that contained mostly human cells at a rate of 50 to 60 per cent, giving hope for potential transplants in the future. “Rat organs have been produced in mice, and mouse organs have been produced in rats, but previous attempts to grow human organs in pigs have not succeeded,” said the senior author Liangxue Lai. “Our approach improves the integration of human cells into recipient tissues and allows us to grow human organs in pigs.” The kidneys were not entirely human as they included vasculature and nerves made mostly from pig cells, meaning they could not be used for transplantation in their current form, but it is still a pretty impressive step. And apart from the kidneys, the embryos were dominated by pig cells, with very few human cells in the brain or central nervous system. Making brains using human and pig cells is very controversial for ethical reasons, so there are tight regulations for this kind of research. Meanwhile, pig cells tend to outcompete human cells during development, so previous experiments have created embryos that are almost entirely pig. The latest work, published in Cell Stem Cell, overcame this by genetically engineering a single-cell pig embryo so that it lacked two genes needed for kidney development. This created a gap within the embryo that could be filled by human cells. “We found that if you create a niche in the pig embryo, then the human cells naturally go into these spaces,” said Prof Zhen Dai of Guangzhou Institutes of Biomedicine and Health, another senior author. The scientists said that being able to incubate a fully human kidney inside a pig would be likely to take many years. “We would probably need to engineer the pigs in a much more complex way and that also brings some additional challenges,” said Miguel Esteban, also of the Guangzhou institute and a senior author. A central challenge would be to allow human nerves and vasculature to develop within the target organ without nerve cells developing in the central nervous system that could lead to a humanised brain. “Even theoretically it’s not clear how you’d do that,” said Ilic. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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The US Food and Drug Administration has cleared the first China-developed cancer drug similar to Merck & Co.’s