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A new, first-of-its kind study has demonstrated that laughter can indeed be good medicine – especially for those with heart disease. Laughter therapy can increase the functional capacity of the cardiovascular system that includes the heart, lungs, arteries and veins, found the yet-to-be peer-reviewed research presented at the annual meeting of the European Society of Cardiology in Amsterdam. Researchers, including Marco Saffi from the Hospital de Clínicas de Porto Alegre in Brazil, found reduced inflammation and better signs of health among coronary artery disease patients who engaged in a course of laughter therapy. They found laughter therapy sessions could cause the tissue inside a patient’s heart to expand, potentially leading to increased oxygen flow through the body. Until now, different treatments without the use of drugs have been studied in coronary artery disease patients, but the benefits of rehabilitation using laughter therapy was not fully assessed, scientists said. In the new study, the impact of laughter therapy on the functional capacity, tissue function as well as markers of inflammation in the bodies of patients with coronary artery disease was evaluated. The condition, which is one of the most common diseases in the world, arises when the heart’s coronary arteries struggle to supply the organ with enough blood, oxygen and nutrients. Scientists conducted a clinical trial involving 26 adults with an average age of 64 from August 2016 to December 2020, measuring each of their oxygen uptake and the widening of their main artery when blood flow increases. Researchers also measured levels of molecules in the patients’ bodies, indicative of inflammation such as interleukin (IL)-6, IL-10, tumour necrosis factor (TNF)-alpha, vascular cell adhesion molecule (VCAM) and intercellular adhesion molecule (ICAM). Thirteen of the patients were assigned to the group that underwent laughter therapy by watching two self-selected TV comedy shows per week. The other 13 served as the control group and watched “neutral documentaries”, scientists noted. They said the study is the first controlled clinical trial to evaluate the impact of rehabilitation using laughter therapy on patients with coronary artery disease. It revealed an increase in the body’s peak oxygen uptake and improvements in tissue function as well as the body’s markers of inflammation. The new findings are in line with previous research that suggested having a good laughter session makes the body release endorphins, which are hormones that reduce stress and inflammation and help the heart and blood vessels relax. Based on the new results, presented at the world’s largest heart conference, scientists say laughter therapy may constitute an “effective form of cardiac rehabilitation in this patient population”. Read More How many steps a day can cut risk of early death (and it’s not 10,000) A broad genetic test saved one newborn's life. Research suggests it could help millions of others Snoring before age 50 is a health ‘red flag’, experts suggest How many steps a day can cut risk of early death (and it’s not 10,000) Experts warn that snoring before you turn 50 is a health ‘red flag’ ‘Boy moms’ called out for dubious logic behind teaching their sons to cook

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Mason Greenwood will leave Manchester United after both parties concluded it would be inappropriate for the forward to continue his career at Old Trafford. United will instead work to find Greenwood a club elsewhere after chief executive Richard Arnold concluded an internal investigation in which he decided that the 21-year-old did not commit criminal offences and that audio of him sounding as though he was trying to force himself upon a woman did not represent the full picture. Criminal charges of attempted rape, assault occasioning actual bodily harm and controlling and coercive behaviour were dropped by the Crown Prosecution Service (CPS) in February. But Arnold determined – and Greenwood agreed – that it would be better if he were to move elsewhere and discussions are continuing as to whether his contract will be terminated or if he should be sold or loaned. Greenwood, who has been suspended by United for 18 months, said he had made mistakes, accepted his reputation was damaged and vowed to be a “better person” in the future. He said: “I want to start by saying I understand that people will judge me because of what they have seen and heard on social media, and I know people will think the worst. I was brought up to know that violence or abuse ... is wrong, I did not do the things I was accused of, and in February I was cleared of all charges [the charges were actually dropped by the CPS when key witnesses withdrew their involvement and new material came to light]. “However, I fully accept I made mistakes ... and I take my share of responsibility for the situations which led to the social media post. I am learning to understand my responsibilities to set a good example as a professional footballer, and I’m focused on the big responsibility of being a father. “Today’s decision has been part of a collaborative process between Manchester United, my family and me. The best decision for us all, is for me to continue my football career away from Old Trafford, where my presence will not be a distraction for the club. I thank the club for their support since I joined aged seven. There will always be a part of me which is United. “I am enormously grateful to my family and all my loved ones for their support, and it is now for me to repay the trust those around me have shown. I intend to be a better footballer, but most importantly a good father, a better person, and to use my talents in a positive way on and off the pitch.” Greenwood, who currently has two years left on his contract, scored 35 goals in 129 games for United and has been capped once by England. Arnold, who said he was shocked when he heard the recording of Greenwood, said it was not a “quick or straightforward process” and noted the alleged victim had dropped her complaint. He stated: “When audio footage and imagery was posted online in January 2022, my feelings were of shock and concern for the alleged victim. Her welfare, wishes and perspective have been central to the club’s approach ever since, as have the club’s standards and values. While we immediately concluded that Mason should be suspended pending investigation, we were also conscious of our duty of care towards him. “While I am satisfied that Mason did not commit the acts he was charged with, Mason’s accepted that he has made mistakes which he takes responsibility for. I am also mindful of the challenge that Mason would face rebuilding his career and raising a baby together with his partner in the harsh spotlight of Manchester United. Further, this case has provoked strong opinions, and it is my responsibility to minimise any distraction to the unity we are seeking within the club.” Read More Mason Greenwood timeline: How the Manchester United star fell from grace

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