Normally when a drug fails to show a clear effect in a final-stage trial, the company developing it

Bernardo Silva has informed Manchester City that he wants to leave the club this summer, with Barcelona and PSG interested in the player.

Scientists are using AI to search planets for alien life. Researchers writing in the Proceedings of the National Academy of Sciences say artificial intelligence can determine with 90 per cent accuracy whether a sample from another planet is biological or not. Scientists hope that their test could be used on samples already collected by the Mars Curiosity rover’s Sample Analysis at Mars (SAM) instrument. The findings could also help tell us more about our own planet, revealing the history of mysterious and ancient rocks found on Earth. “The search for extraterrestrial life remains one of the most tantalizing endeavors in modern science,” said lead author Jim Cleaves of the Earth and Planets Laboratory, Carnegie Institution for Science, Washington, DC. “The implications of this new research are many, but there are three big takeaways: First, at some deep level, biochemistry differs from abiotic organic chemistry; second, we can look at Mars and ancient Earth samples to tell if they were once alive; and third, it is likely this new method could distinguish alternative biospheres from those of Earth, with significant implications for future astrobiology missions.” The technique was built by giving an artificial intelligent system data about 134 known samples, with information about whether they are biotic or abiotic. To test it, it was then given new samples – including those from living things, remnants of ancient life and other abiotic samples that did not point to life, such as pure chemicals. The system also started predicting another kind of sample type, dividing the biotic ones into “living” and “fossils”. That means it could tell the difference between a freshly harvested leaf and something else that died long ago, for instance. In the future, the technology could become even more advanced and detect other aspects of life. “This routine analytical method has the potential to revolutionize the search for extraterrestrial life and deepen our understanding of both the origin and chemistry of the earliest life on Earth,” said Robert Hazen, of the Carnegie Institution for Science, one of the leaders of the research. “It opens the way to using smart sensors on robotic spacecraft, landers and rovers to search for signs of life before the samples return to Earth.” Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Men’s college basketball traditional powers Kansas and North Carolina will play each other in regular-season games in 2024 and 2025

The head of the Switzerland's dairy association says the country will import more cheese than it exports this year for the first time

Liverpool midfielder Harvey Elliott urges Mohamed Salah to stay at Anfield following strong summer interest from Al Ittihad in Saudi Arabia.

A law enforcement task force will continue to work "full time" to gather evidence after a suspect has been charged in some of the Gilgo Beach killings, including further investigation into a string of other human remains found scattered across Long Island more than a decade ago, a top investigator told CNN.

Jordan Henderson is set to face a decision over whether to stay at Liverpool amid interest from Saudi Arabia and the possibility of a lucrative transfer. Liverpool are yet to receive an offer for their captain but Henderson has emerged as a target for Al Ettifaq and their new manager Steven Gerrard. Henderson, 33, has two years left on his contract at Anfield but could face a battle for his place after Jurgen Klopp spent £95m revamping his midfield with the signings of World Cup winner Alexis Mac Allister and Dominik Szoboszlai. Now Liverpool’s Champions League-winning skipper must determine whether to extend his 12-year stay at Anfield or join a host of players, including his former teammate Roberto Firmino, in signing up to go to Saudi Arabia. Euro 2024 is likely to be a factor in his thinking. Henderson forced his way back into England’s starting 11 during last winter’s World Cup and remains keen to play for his country. Klopp may be reluctant to lose the former Sunderland player, who made 43 appearances last season, after three other midfielders – vice-captain James Milner, Naby Keita and Alex Oxlade-Chamberlain – left at the end of the season. The 2020 Footballer of the Year succeeded Gerrard as Liverpool captain in 2015 and led them to their first English league title in three decades five years later. Read More The reason why Liverpool’s worst season under Jurgen Klopp can be a one-off Liverpool thought they’d bought the future – but two wrong moves left them counting the cost Why England will head into 2024 with their sense of optimism restored

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A Russian court has fined Google for failing to store personal data on its Russian users, the latest in a series of fines on the tech giant amid tensions between Russia and the West over the war in Ukraine

Liverpool captain Jordan Henderson has acknowledged how much of a huge loss to the club the departures of James Milner and Roberto Firmino will be. The pair, whose signings in the summer of 2015 pre-date the arrival of current manager Jurgen Klopp by a few months, have played an integral role in their recent success. Both will depart when their contracts expire at the end of the season as Champions League and Premier League winners but Henderson believes their importance extends beyond just on the pitch. On Milner’s contribution, the England midfielder told the PA news agency: “A tremendous amount of value to the team. “I think the manager said it perfectly in that we wouldn’t have achieved anything without Millie. He is such a big character and such a big leader within the team. “It will definitely be strange not seeing him at Liverpool next season, he’s been incredible ever since he came to the club. “He helped me a lot and other players around him and is probably taken for granted a little bit as a player from the outside but from the inside he has got so much respect from all of the players and all of the staff and we wish him all the very best in whatever his next chapter looks like.” Firmino, who has returned to training this week after missing six matches with a muscle problem, is due a particularly emotional farewell in Liverpool’s final home match of the season against Aston Villa on Saturday. The much-loved Brazil international travelled with the squad for Monday’s win over Leicester and the away fans dedicated more than 10 minutes of the second half to singing about him. “He will be a huge miss also,” added Henderson, who was speaking at an NHS Big Tea event in Crewe in his role as an ambassador for NHS Charities Together. “The good energy he gives the team is always so positive, he’s always in a good mood and smiling but his quality on the pitch is unbelievable. “Thankfully he is back in training and hopefully he can be ready if not at the weekend then maybe the last game of the season. “But you have seen the reception he got on Monday from the fans and rightly so. I am sure that will be the case again on Saturday.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Luke Wood says playing for Lancashire ‘my pride and joy’ ahead of Blast opener Manager of the season contender Unai Emery ‘trying to improve every day’ Barry Bannan dedicates Sheffield Wednesday’s stunning comeback to Darren Moore