A treatment for acute migraines has been approved for NHS use for the first time, with experts saying the move could be a “step-change” for thousands of people who suffer from the condition. The National Institute for Health and Care Excellence (Nice) said its final draft guidance on Rimegepant “addresses the high unmet need for treatment options for acute migraine”. Rimegepant, also known as Vydura and made by Pfizer, will be available to adults who have tried at least two triptans – medication usually given to tackle headaches or migraines – but found they did not work well enough. It can also be administered to those who are not able to take triptans or have an intolerance, or patients who have tried nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol. Helen Knight, director of medicines evaluation at Nice, said: “Migraine is a condition described in comments to Nice from carers and people with migraine as an invisible disability that affects all aspects of life including work, education, finances, mental health, social activities and family. “Today’s final draft guidance addresses the high unmet need for treatment options for acute migraine, once again demonstrating our ability to ensure clinically and cost-effective medicines are available to those who need them as quickly as possible.” Rimegepant is taken as a wafer, which dissolves under the tongue and works by stopping the release of a protein around the brain called calcitonin gene-related peptide. In July, the medicine was recommended as an option for preventing episodic migraines in adults who have at least four and fewer than 15 attacks per month if “at least” three other treatments have not worked. This is the first and only Nice-recommended medicine that can help alleviate the misery of acute migraines, and may be considered a step-change in treatment Helen Knight, Nice Under the latest guidance, it will also be used to relieve symptoms of a migraine, which can include pain, nausea and sensitivity to light, but also painless symptoms such as temporary visual disturbances known as “aura”, which Nice said “is not well managed with existing treatments”. The recommendation is expected to benefit about 13,000 people. Ms Knight added: “This is the first and only Nice-recommended medicine that can help alleviate the misery of acute migraines, and may be considered a step-change in treatment.” Migraine is an incredibly misunderstood condition that can have a significant impact on all areas of life, including ability to work, maintain relationships and mental health Robert Music, The Migraine Trust Robert Music, chief executive of The Migraine Trust, said the Nice guidance “provides people with migraine valuable options to help reduce the pain and length of a migraine attack”. “It brings new hope,” he added. “It will especially benefit those who have not found a treatment that works, those who get debilitating side effects – including medicine overuse headache – from them, and those with cardiovascular disease who cannot take existing treatments. “Migraine is an incredibly misunderstood condition that can have a significant impact on all areas of life, including ability to work, maintain relationships and mental health.” Read More NHS winter resilience fund announced by Government NHS reliance on paper notes ‘stopping trusts from realising full potential’ Recession fears as UK economy shrinks by more than expected in shock decline Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live

Lewis Capaldi is taking some time for himself.

Seamer Lockie Ferguson will captain New Zealand for the first time on the international stage during their three-match 50-overs tour of Bangladesh...

Royal Mail reported an operating loss of £1 billion ($1.25 billion) after the beleaguered delivery service endured a

Cell phones, tablets and smartwatches will be largely banned from classrooms in the Netherlands from January 1, 2024, the Dutch government said on Tuesday, in a bid to limit distractions during lessons.

Atlanta Braves Rumors: Jared Shuster is sent down again. Chipper Jones trolls his former teammate John Smoltz. Could a free-agent move be in the cards?

Twitter users are still reeling from the platform’s abrupt branding change to "X". The social media app changed its branding on Monday morning after scarcely a day’s notice, with many mocking the new look of the platform. Channel 4 got in there early by reminding Elon Musk, Twitter’s owner, of the time they tried to launch a major rebrand – and it didn’t quite stick. The broadcaster’s social media account posted: “People still call our streaming service 4OD so good luck”. Sign up to our free Indy100 weekly newsletter Channel 4’s 4OD was one of the first major on-demand TV services in the UK, where many people rediscovered classic shows such as Friends, Gogglebox and How I Met Your Mother. Eventually, however, network executives decided it was time to fix something that definitely was not broken, rebranding the service as All 4. The moniker clearly didn’t stick. Twitter executives will hope they have a little more success with their change. Meanwhile, billionaire Elon Musk has already faced significant criticism for the way he has handled the company since taking it over last year. He fired 80 per cent of the tech company’s staff last year, many finding out in brutal circumstances by opening their laptops and discovering they no longer had a job when the machine would not log them in anymore. The result, many commentators have agreed, is a degraded product, with major glitches including all links to external websites temporarily failing, and day-long caps on how many tweets users can look at. Musk has also restored the accounts of thousands of previously suspended users, including neo-Nazi and QAnon accounts. He also tried to restore former President Donald Trump’s account – but Trump wasn’t having any of it, preferring to stick with his own app, Truth Social. Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Liverpool are taking on Brighton and Hove Albion at the Amex Stadium today as both sides look to bounce back from chastening defeats in the Premier League last weekend. Liverpool were on the receiving end of that disastrous VAR call which saw Luis Diaz have a goal incorrectly ruled out despite checks confirming he was onside. They enjoyed a Europa League win over Union Saint-Gilloise on Thursday but Jurgen Klopp has warned his side they are facing a dangerous opponent in Brighton. “We expect a really tough game against one of the best sides in the league, the best-coached team in the league, I would say.” Brighton, however, were thrashed 6-1 by Aston Villa last weekend with manager Roberto De Zerbi concerned that his squad are not equipped to play European football alongside domestic duties. They come into this one with several injury concerns, after salvaging a late draw at Marseille in the Europa League in midweek. Follow all the latest score and updates from Brighton vs Liverpool below and get all the latest Premier League betting sites offers here. Read More Liverpool’s new double-act are surprising even Jurgen Klopp

SCOTTSDALE, Ariz.--(BUSINESS WIRE)--Jul 11, 2023--

Georgia Stanway stood on her own, isolated in a pocket of space. With her hands in the air, she saw the move before it unfolded. England had been searching for the gaps against Colombia, but going behind only sharpened their focus. After the explosion of Colombia’s goal, England could have lost their heads, but Stanway found hers and then the space. One thumping finish from Alessia Russo later and England were heading towards the semi-finals of the World Cup. Arguably, no one deserves this semi-final more than the Bayern Munich midfielder. Stanway had to be disciplined when Keira Walsh was injured, constrained when Lauren James was given the keys to England’s creative output. With James suspended, Stanway was released. With the bite in midfield to combat Colombia’s physicality, then the cool to pick holes in their defensive shape. Having to play through four games on a yellow card has meanwhile forced Stanway to do it all on a knife-edge, controlling the aggression when one wrong moment would have taken her semi-final away. The Lionesses also had to earn it, in a difficult contest that passed by in waves of England control and frantic Colombia pressure. The atmosphere fed into it: Colombia turned up in their numbers, dominating the 75,000 capacity stadium and its soundtrack; hostile when England had possession, electric when Colombia flew forward, the noise rising further when Linda Caicedo drove them on. England faced the battle they had been expecting. Then Colombia scored and a tournament that has been defined by obstacles was presented with a new one, as England trailed for the first time in the World Cup. But Stanway epitomised how England responded and took to their task. It was a different type of resilience to what England showed at the end, continuing to show, on the ball and off it. She showed her intelligence, baiting Colombia players in and waiting a moment, before releasing it. As a whole, there wasn’t a panic. Lauren Hemp’s equaliser was scrappy, arriving in a mess in the penalty box, but it had been coming. If anything, going behind sharpened England. England’s plan was clear enough: they had their control and build-up, neat passages of play as they found the gaps in Colombia’s shape, threading passes through for Stanway and Ella Toone to turn. England were sharper than against Nigeria, even if the final ball was missing. With James’ two-match ban forcing another rethink for Wiegman, the England manager combined something new with something old. The midfield three returned, with Stanway and Toone deployed as twin-eights in front of England’s back five. But Colombia reached the quarter-finals by ensuring those spells do not last for long. Between England’s passing moves, Colombia rattled them and threatened with their quality, thriving off the match being in a scrappy and disrupted state. The South Americans broke England’s passing up and tore whatever momentum they were building down, a series of fouls to pause England’s flow. Then there were the challenges: Ana Guzman barging into Hemp, then leaving an arm on Rachel Daly, Santos pulling Stanway back by the arm. And in those spells England were sloppy, five-yard passes hit straight out of play, allowing themselves to take the safe or easy option, turning down the chance to turn. When Santos’ cross drifted over the head of Mary Earps, England were faced with the worst. The response was crucial. In the six minutes of added time at the end of the first half, England stuck to how they had set up to play. The way Colombia were positioned allowed England to have those gaps in midfield and there was always a player to find. England had to be patient, to move it quickly enough and have the confidence to do more when they could turn. Hemp everywhere across the frontline, taking pressure off England with bursts downfield, Russo struggling to hold the ball up, but producing the devastating finish when it counted. England dropped deep, perhaps too early, but they did so safe in the knowledge that they had Millie Bright in this form. Bright was faultless as England defended their box, alongside the exceptional Alex Greenwood. This wasn’t perfect but this tournament has been about finding a way through. England are enjoying it, while Stanway just offers them that bit more. Read More England set up old rivalry on new stage thanks to Alessia Russo magic How many games will Lauren James miss at Women’s World Cup after red card? Who and when do England play next? Lionesses’ route to the World Cup final ahead of semi-final

Israeli security forces say they demolished the West Bank home of a Palestinian man accused of carrying out a deadly shooting attack earlier this year

Israel’s figurehead president speaks to Congress in an appearance aimed at demonstrating what he calls the “unbreakable bond” between Israel and the U.S. The show of unity Wednesday is coming despite U.S. concerns over Prime Minister Benjamin Netanyahu’s controversial judicial overhaul and ongoing settlement construction in the West Bank