One of the few remaining pro-democracy parties in Hong Kong has voted to dissolve itself, joining a growing list of organizations that have disbanded as authorities crack down on dissent

Kylian Mbappe snatched a famous Champions League victory from Newcastle’s grasp with a controversial penalty in the eighth minute of stoppage-time to earn Paris St Germain a 1-1 draw at the Parc des Princes. Defender Tino Livramento was harshly adjudged to have handled Ousmane Dembele’s cross to allow the France superstar to finally beat goalkeeper Nick Pope from the spot on a night when Eddie Howe’s men came within seconds of a win which would have set them up perfectly for their final Group F fixture against AC Milan at St James’ Park. They led through Alexander Isak’s 24th-minute strike and looked to have survived a second-half onslaught with Pope saving from Mbappe, Dembele and substitute Bradley Barcola, but they headed back to Tyneside wondering what might have been after the draw kept their hopes of a place in the last 16 alive, but only just. Victory over the Italians combined with defeat for PSG at Borussia Dortmund, who have already qualified, would see the dream realised, but their fate is now out of their own hands. That is harsh on Howe’s injury-ravaged squad, who turned in a performance of real character in Paris with Bruno Guimaraes Livramento, Pope, Miguel Almiron and – as the game became increasingly stretched – Anthony Gordon shining in particular. Mbappe started in ominous mood as he and Lee Kang-in combined repeatedly down the left and Pope had to save the PSG skipper’s audacious flick with his feet after Randal Kolo Muani had played full-back Achraf Hakimi into space with an equally deft touch. However, the visitors should have taken a 12th-minute lead when Almiron dispossessed Hakimi and crossed low to Isak at the near post only to see the striker lift his first-time shot agonisingly over. They did with 24 minutes gone when full-back Livramento embarked on a scything run which took him past Dembele, Hakimi, Fabian Ruiz, Milan Skriniar, Manuel Ugarte and Lee before he fed Almiron on the right. The Paraguay international curled a shot towards the far post, where goalkeeper Gianluigi Donnarumma could only push the ball out to Isak, who gleefully slammed it into the net. Pope had to come to Isak’s rescue after he lost possession and Dembele raced away and tried to steer the ball inside the far post as PSG responded, but for all their attacking flair, the French side were struggling to break down their English opponents. Skriniar was perhaps fortunate not to be penalised for handball as he made a last-ditch attempt to deny Isak a clear run on goal in stoppage-time, but Pope was grateful for the sizeable presence of Fabian Schar in front of him to keep out Dembele’s well-struck attempt from Mbappe’s cross. Isak was almost through on goal again within seconds of the restart after running on to Joelinton’s defence-splitting pass before eventually being snuffed out by the recovering blue shirts and, with Anthony Gordon keeping the PSG defence occupied, frustration was mounting among the home ranks. They might have been back in it, however, had Pope not raced from his line to block Dembele’s 56th-minute toe-poke and the keeper was rewarded when Mbappe completely missed his as he attempted to acrobatically volley home the rebound. The Magpies edged ever deeper as Luis Enrique’s men fought desperately for a way back into the game and they almost got it with 66 minutes gone when Mbappe tricked his way past Schar and crossed for Barcola, whose point-blank effort was brilliantly saved by Pope. Barcola fired wastefully into the side-netting after getting in behind the visitors’ defence and Gordon survived a VAR review for a penalty after Hakimi had gone down under his challenge with Newcastle visibly tiring. Pope blocked Mbappe’s 87th-minute strike at his near post and saw the France international thump the rebound inches wide, but he was finally beaten at the death after Polish referee Szymon Marciniak had reviewed the incident in which Dembele’s cross appeared to hit Livramento’s side and loop up on to the underside of his arm and belatedly awarded a spot-kick. Read More Newcastle must show ‘top team attitudes’ to beat PSG, says Nick Pope Rumours: Sancho and Antony head up Man Utd’s 15-player sale list PSG vs Newcastle LIVE: Champions League result and reaction PSG vs Newcastle LIVE: Champions League result and reaction As Man City celebrated their past, Phil Foden reminded them of their glorious present Late heartbreak for Newcastle and Manchester City march on in Champions League

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Footage shows the moments before two Swedish people were shot dead in Brussels on Monday night (16 October). In a video circulating on social media, people can be seen running for their lives as gunshots ring out in the centre of Belgium’s capital city. Belgian authorities have raised the terror alert to its highest level in Brussels and the second-highest level across the rest of the nation. The violent incident came ahead of a qualifier game for Euro 2024 between Sweden and Belgium at the Heysel Stadium, some three miles away. Belgian media reported the suspected assailant was shot in a cafe in the Schaerbeek neighbourhood of Brussels on Tuesday morning. Read More Police on scene of Brussels shooting as Belgium raises terror alert to highest level Richard Madeley asks British-Palestinian MP if family knew Hamas attack was imminent Putin arrives in China on second foreign trip since March 2023

Google says it has made a significant step in identifying disease-causing genes, which could help spot rare genetic disorders. A new model named AlphaMissense is able to confidently classify 89 per cent of all possible “missense” variants in genes, identifying whether they are likely to cause diseases or benign. That compares with just 0.1 per cent of all missense variants that have been confidently classified by human experts. Missense variants happen when a single letter is substituted in the DNA, which in turn leads to proteins with a different amino acid. That small change can have significant effects – Google likened it to the way that changing a letter in one word can change the meaning of the whole sentence. Most of those variants are benign: the average person has more than 9,000 of them. But some of them can be disastrous, leading to rare genetic diseases. The new AlphaMissense looked at existing information about missense variants, and how commonly they are seen in humans and closely-related primates. It looked for those that were rarely seen, classifying them as pathogenic, and from that was able to use that information to analyse other protein sequences – giving not just a verdict on whether they were likely to cause problems, but also how confident it was. Experiments, conducted by humans, which look to find those mutations are expensive and slow: they require people to examine each unique protein and designed separately. Google says that the new system means that researchers can “preview” those results for thousands of proteins at a time, helping them decide where to focus. The company has used its systems to release a vast catalogue of “missense” mutations, so that researchers can learn about what effect they have. In some cases, those variations can lead to conditions such as cystic fibrosis, sickle-cell anaemia, or cancer, and understanding them could be key to researchers studying ways to treat or prevent those diseases. It is just the latest health breakthrough from Google’s Deepmind division, which is looking to use artificial intelligence to both identify and treat a variety of conditions. The new system was built on AlphaFold, the breakthrough model that helped unfold proteins, the building blocks of life. The research is described in a new paper, ‘Accurate proteome-wide missense variant effect prediction with AlphaMissense’, published in the journal Science. The catalogue is being made “freely available to the research community”, Google said, and the company will release the code behind the AI system. Read More BBC removes some Russell Brand content as monetisation suspended on YouTube Google Bard can now link to Gmail and other apps to help with responses Long-form video content is here to stay, says YouTube UK boss