By Nathan Gomes (Reuters) -CarMax on Thursday posted a lower-than-expected quarterly profit, hurt by weakening demand for preowned vehicles, sending

By Lucia Mutikani WASHINGTON (Reuters) -The number of Americans filing new claims for unemployment benefits fell to a nine-month low

NEW YORK (AP) — Vincent Trocheck scored twice, Chris Kreider and Artemi Panarin each had a goal and an assist, and the New York Rangers downed the Detroit Red Wings 5-3 on Tuesday night.

By Lewis Krauskopf NEW YORK Investors in the coming week will get a look at the state of

Travis Kelce once revealed his dating dealbreakers on the ‘Watch What Happens Live!’ show

Almost 300 babies are born in the UK with sickle cells every year, according to the Sickle Cell Society, and the effects of sickle cell disease are believed to impact thousands. Yet, many people may not even know what sickle cells are or what living with the condition means. What is sickle cell disease? In most people, red blood cells are disc shaped and move easily through the blood vessels. But if you have sickle cell disease, your red blood cells are shaped like a sickle (similar to a crescent moon). This stops them moving with ease through the body and blood flow becomes restricted. Sickle cell disease isn’t actually one specific disease – it refers to a group of conditions affecting people with sickle cells, which range in severity.The conditions are inherited and predominantly affect people from African and Caribbean family backgrounds. What are the symptoms of sickle cell disease? Symptoms begin early in childhood and can sometimes be debilitating. How each individual is affected may vary, but the main symptoms are anaemia, an increased risk of infections, and pain. This includes extremely painful episodes called ‘sickle cell crisis’, which happens when blood flow to certain parts of the body become blocked. According to the NHS, these episodes can last for days and require hospitalisation. Other issues are associated with the condition too, including problems with the lungs, delayed growth in childhood, higher risk of stroke, leg ulcers and sight/vision problems.How is it diagnosed? Sickle cell disease is usually picked up during pregnancy or shortly after birth, although a blood test can be given at any time to see if someone has the condition or carries sickle cell genes. In parts of the country, pregnant people will be offered a test to see what the chances are of their child having sickle cells. Infants can be checked for the cells through a heel prick test.How do you treat it? Treating sickle cell disease is usually a lifelong process to help people with pain and to stay as healthy as possible. Treatment takes place in specific sickle cell centres and those living with it are encouraged to take care of their health, no matter the severity of their symptoms. Managing pain is a huge part of treating sickle cell disease. Staying hydrated can be helpful, as well as avoiding sudden temperature changes, like getting into a cold shower or diving into water. According to the NHS, Hydroxycarbamide (hydroxyurea) may be recommended, which is taken as a pill once a day. This can lower the quantity of other blood cells and requires careful monitoring, however. Some people may also be able to have a medicine called crizanlizumab, either on its own or alongside hydroxycarbamide, usually injected into a vein every four weeks. To prevent infections, many people with sickle cell disease will take daily antibiotics. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live TikTok has gone wild for adult gymnastics – here’s what you should know Man explains why he swapped veganism for raw meat diet: ‘I feel great’ Rugby star Ugo Monye: Boarding school shaped my career and my personality

By Shadia Nasralla, Ron Bousso and America Hernandez LONDON/PARIS Shell and TotalEnergies reported sharp falls in second-quarter profit

A string of disturbing revelations of “inhumane and degrading” maltreatment of older and disabled people at Romanian care homes have sparked concerns over the country’s capacity to adequately care for its socially vulnerable

Head coach Steve Kerr said the United States "want to finish this right" as they prepare to face Canada in the Basketball World...

Joe Rogan said, 'I’ve seen like custom cars they’ve made for him, like the seat basically sits where the back seat should be'

Dillon Danis says Nina Agdal inspired 'Gold Digger,' Jamie Foxx's hit collab with Kanye West

Iam Tongi was crowned the winner of Season 21 with Megan Danielle coming second and Colin Stough third