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Our canine companions could soon be enjoying much longer lifespans, if a drug which claims it can extend dogs’ lives eventually gets approved. The drug, made by a tech firm in California, just cleared a vital hurdle to doing just that, after it got partial approval by regulators in the US. Loyal, a San Francisco-based company founded in 2020, has been researching how it can increase dogs’ lifespans – in particular larger breeds, which tend to die younger. Large and “giant” breeds tend to live to between eight and 12 years. Smaller dogs, such as Chihuahuas, can keep going to the ripe old age of 20. Loyal’s main product, the catchily-titled LOY-001, is designed not only to extend dogs’ lives but also maintain their quality of life. Now, it has passed the “reasonable expectation of effectiveness” test, set by regulators at the US’ Food and Drug Administration. Loyal’s chief executive, Celine Halioua, said: "Loyal was founded with the ambitious goal of developing the first drugs to extend healthy lifespan in dogs. "This milestone is the result of years of careful work by the team. We'll continue to work just as diligently to bring this and our other longevity programs through to FDA approval." Selective breeding of dogs has caused higher levels of hormones which help the animals grow faster. That is also believed to reduce their lifespan, the company said. Big dogs tend to have more of this hormone than their smaller counterparts. Animal rights activists are not yet convinced. Some experts fear it will only serve to extend animals’ suffering. Loyal, on the other hand, says the drug aims to treat doggy diseases which are associated with ageing through preventing them, rather than waiting for the animals to get sick before treating them. The company said that the drug could be available to US customers as early as 2026. So that’s plenty of time for walkies between now and then. How to join the indy100's free WhatsApp channel Sign up to our free indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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Ukrainian president Volodymyr Zelensky called on Canada to “stay with” his country in its war against Russia, in his first visit to the country since the start of the invasion. The Ukrainian president arrived in Canada’s capital Ottawa late on Thursday night and addressed the parliament on Friday where he sought to bolster support from Western allies for Ukraine’s war. “Moscow must lose once and for all. And it will lose,” Mr Zelensky said during his address on Friday. He repeatedly thanked Canadians for financial support and for making Ukrainians fleeing war feel at home in Canada, prompting a number of standing ovations from dignitaries and parliamentarians. Mr Zelensky said Canada has always been on the “bright side of history” in fighting previous wars and said it has helped saved thousands of lives in this war with its aid to Kyiv. Canada is home to about 1.4 million people of Ukrainian descent, close to 4 per cent of the population. More than 175,000 Ukrainians have come to Canada since the war started and an additional 700,000 have received approval to come as part of an initiative that supports temporary relocation of those fleeing the war. The initiative allows for an open work permit for three years with pathways to permanent residency and citizenship. In his speech Mr Zelensky linked the suffering of Ukrainians now to the 1930s genocide caused by Stalin, when the Soviet leader was blamed for creating a man-made famine in Ukraine believed to have killed more than 3 million people. He also noted that it was in Edmonton, Canada, where the world’s first monument was erected in 1993 to commemorate the Ukrainian Famine-Genocide. The Ukrainian president expressed hope that a monument would one day be raised in Canada to Ukraine’s victory over Russia’s invasion, “maybe in Edmonton.” “I have a lot of warm words and thanks from Ukraine to you,” Mr Zelensky said in prime minister Justin Trudeau’s office before his speech. “You have helped us on the battlefield, financially and with humanitarian aid. ... Stay with us to our victory.” It is Mr Zelensky’s first visit to Canada since Russia invaded Ukraine in February 2022. He previously addressed the Canadian Parliament virtually after the war started. Mr Trudeau called the visit an opportunity to show Mr Zelensky “how strongly and unequivocally we stand with Ukraine” and announced an additional $650m Canadian (£394m) over three years for 50 armored vehicles that will be built in Canada. “We are shifting our approach to provide multiyear assistance to ensure Ukraine has the predictable support it needs for long term support,” Mr Trudeau said at a news conference. Mr Zelensky and Mr Trudeau also attended a rally in Toronto with the local Ukrainian community late Friday. The visit comes as cracks begin to appear in the united Western front backing Ukraine for the last 19 months of gruelling war against Russia with hard-right Republicans led by Donald Trump becoming increasingly hostile to sending more aid and key partner Poland saying it will no longer send arms to Kyiv. Ukrainian troops are struggling to take back territory that Russia gained over the past year and with no end to war in sight, Mr Zelensky has a hard road ahead to keep the momentum in favour of Kyiv going, a task for which allies like Canada play a key role. Additional reporting by agencies Read More Ukraine-Russia war - live: Putin’s Black Sea navy HQ hit in missile strike as Kyiv breaches frontline defences Cracks in Western wall of support for Ukraine emerge as Eastern Europe and US head toward elections Biden has told Zelensky US will give Ukraine coveted ATACMS long-range missiles, report says Zelensky makes passionate plea to US lawmakers on key Washington visit

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PARIS & SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--May 22, 2023--

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