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One of the scientists whose work pioneered the development of medications such as Ozempic and Wegovy has revealed why life may become “so miserably boring” after two years of using the drug. Ozempic is an FDA-approved medication used for the treatment of type 2 diabetes. It works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), which regulates blood sugar levels and slows down the rate at which food leaves the stomach, often creating the feeling of fullness. These semaglutide injections – sold under the brand names Ozempic and Wegovy – have soared in popularity as many people, including Hollywood celebrities, have used it for weight loss. What’s more, people have also found Ozempic has been effective in curing their addictive habits, like drinking, smoking, shopping, or nail biting. However, because of Ozempic’s increasing popularity, it has led to national shortages of the type 2 diabetes treatment – leaving those who actually need it without. In an interview with Wired, professor Jens Juul Holst – who received the Warren Alpert Foundation Prize in 2021 for his work developing treatments based on the GLP-1 hormone – spoke about the effects of Ozempic, and why he believes many people will stop taking the medication after just a few years. “What happens is that you lose your appetite and also the pleasure of eating, and so I think there’s a price to be paid when you do that,” Holst told Wired. “If you like food, then that pleasure is gone. The craving for food for some people is taken away when they take GLP-1 drugs.” He continued: “That may eventually be a problem, that once you’ve been on this for a year or two, life is so miserably boring that you can’t stand it any longer and you have to go back to your old life.” Holst added that medications like Ozempic and Wegovy have been on the market since 2005, though studies show that these people don’t stay on them for very long. “It’s just like every other drug, they don’t stay on it for many reasons,” he explained. “One of the reasons, as I said, is that once you have tried it and you realise you’ve lost interest in food, then that may be enough.” “We don’t know why people stop taking these drugs, but we know for a fact that they do stop. They do that all over the world.” A 2020 study found that 70 per cent of people who took GLP-1 drugs for type 2 diabetes stopped taking them within two years. However, this could pose a problem for many patients taking semaglutide injections. Research has found that people who stopped taking Ozempic or Wegovy for weight loss experienced weight rebound. A trial published in April 2022 saw participants gain back two thirds of the weight they had lost after 68 weeks of taking semaglutide. As for celebrities who use the once-weekly injection for weight loss, despite not having diabetes or clinical obesity, Hans instead called attention to the “many terrible problems” that those with diabetes have struggled with by not having drugs like Ozempic readily available. “Have you ever visited a diabetes hospital? It’s really deplorable,” he said. “People come in with amputated limbs and compromised cognitive functions and heart problems or they can barely move – they’re miserable and depressed. It’s really serious. There is so much you can improve with a drug that is not only a weight-loss drug but is also an anti-diabetic.” Amidst the popularity of semaglutide injections, the US Food and Drug Administration has issued warnings for consumers not to use off-brand versions of Ozempic or Wegovy, because they may not include the same GLP-1 hormone used in approved medications. Earlier this month, agency officials reported problems with patients using compounded versions of semaglutide – which combines traditional semaglutide with other ingredients. These drugs are not FDA-approved, and the agency does not verify the safety or effectiveness of compounded drugs. Consumers should only use drugs containing semaglutide with a prescription from a licensed health care provider and obtained from a state-licensed pharmacy or other facilities registered with the FDA, the agency said. Read More What is ‘Ozempic face’? Doctors warn about facial ageing side effect of diabetes medications How does Wegovy work? The ‘game changing’ weight loss drug beloved by Hollywood FDA warns against using off-brand versions of Ozempic, Wegovy for weight loss Scientist behind Ozempic says drug can make life ‘so miserably boring’ Pregnant Stassi Schroeder admits she wants to ‘try’ Ozempic after giving birth Doctors warn about ‘Ozempic face’ side effect of medications

French president Emmanuel Macron held a crisis meeting as Francewas gripped by violence for a second day on Thursday over the police killing of a teenager of North African descent. Clashes first erupted on Tuesday night in and around the Paris suburb of Nanterre, where the teen, identified as Nahel M, 17, was shot during a traffic check. Nahel's last name has not been released by authorities or his family. His mother has called for a silent march on Thursday in his honour in the square where the teenager was killed. "I lost a child of 17-year-old, they took my baby," the mother, who has not been named, said in a TikTok video. "He was still a child, he needed his mother. This morning he gave me a big kiss and told me he loved me. I told him be careful and I loved him." According to his mother, they both had left the house together. While he went to get a McDonalds takeout, she left for work. "And then I am told they shot my son, what can I do," the heartbroken woman said. "I only had him. I didn't have 10 like him. He was my life, my best friend. He was my son, He was my everything." The victim's grandmother, who also remained unidentified said: “I will never forgive them. My grandson died, they killed my grandson. We are not happy at all, I am against the government." “They killed my grandson, now I don't care about anyone, they took my grandson from me, I will never forgive them in my life, never, never, never.” A video shared on social media showed two police officers beside a Mercedes AMG car, with one shooting at the teenage driver at close range as he pulled away. He died shortly afterward from his wounds, the local prosecutor said. The teenager, who was too young to hold a full license in France, was driving illegally, a source familiar with the investigation told Reuters. The Nanterre prosecutor said the boy failed on Tuesday to obey the officers’ orders. A lawyer for Nahel's family, Yassine Bouzrou, said they want the police officer prosecuted for murder instead of manslaughter. He said he would file an additional complaint for false testimony over the allegation that the victim had tried to run over the police officer. Police arrested 150 people during a second night of unrest, interior minister Gerald Darmanin said, as public anger spilled onto the streets in towns and cities across the country. Some 40,000 police officers will be deployed overnight to quell violence that engulfed cities and towns, the ministry said, adding that 5,000 alone will be sent to Paris. President Macron said the killing was “inexplicable and inexcusable” and called for calm. “Nothing justifies the death of a young person,” he told reporters in Marseille on Wednesday. Read More Paris riots – latest: Police officer who shot teen dead under investigation for homicide as 150 arrested Paris riots: Video shows police interacting with teenager during fatal traffic stop French police, protesters clash in multiple towns after 17-year-old killed by police Who is Nahel? The teen shot dead by police in France France mobilising 40,000 police to stop fresh violence after officer kills teenager Russia has ‘arrested’ General Armageddon over Wagner mutiny – war news live

Brittany Allen previously appeared in 'Project Runway' Season 18