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The feeling of hunger could be a simple way to stop the ageing process, according to a new study. Researchers at the University of Michigan tricked fruit flies into feeling hungry which resulted in the insects living longer – even when they eat their calorie intake. The study - published in Science - suggests that the perception of insatiable hunger alone can generate the anti-aging effects of intermittent fasting. (And since it’s the perception rather than actual hunger, it means the bugs don’t actually have to starve). Sign up to our free Indy100 weekly newsletter "We've sort of divorced [the life extending effects of diet restriction] from all of the nutritional manipulations of the diet that researchers had worked on for many years to say they're not required," physiologist Scott Pletcher said, as per Michigan Medicine. "The perception of not enough food is sufficient." You may have heard the term intermittent fasting before, as it is a popular diet fad that consists of going for extended periods of time without eating, followed by a period of eating normally, according to Bupa. Despite its popularity, evidence supporting its benefits is limited in terms of research on humans. Perhaps you’re thinking… why fruit flies? Well, the insects actually share 75 percent of the same disease-related genes as us, while also sharing similar qualities to mammals in terms of their metabolisms and brains, according to Science Alert. In the research, branched-chain amino acids (BCAA) essential nutrients that appear to trigger feelings of fullness in flies when consumed, were used. The fruit flies maintained their hunger through getting fed snacks low in BCAA and their hunger was noticed through how much the insects ate from a buffet of food hours after eating the snack. More food was consumed by flies who earlier ate a low-BCAA snack, and they choose protein over carbs, focusing on what their hungry bodies needed. From learning this, the team directly activated the neurons in fruit flies that trigger hunger responses, they found these hunger-stimulated flies also lived longer. "Demonstration of the sufficiency of hunger to extend life span reveals that motivational states alone can be deterministic drivers of ageing," Pletcher and colleagues wrote in the findings. Along with fruit flies, rodents have also been part of the study and both seems to suggest calorie restriction can extend life and is good for our health too. Though of course, more extensive research is required to see whether or not this is also the case with humans. Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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Eddie Howe has vowed to adopt a siege mentality once again as Newcastle prepare for a first Champions League campaign in 20 years. The Magpies have dragged themselves from the thick of a Premier League relegation fight when the club’s new owners took control in October 2021 to Europe’s top table in the space of a remarkable 19 months. They have done so with the help of a £250million-plus investment, provided in large part by Saudi Arabia’s Public Investment Fund, which holds an 80 per cent stake, and the source of that wealth has prompted concerted criticism, with human rights campaign group Amnesty International in particular voicing concerns over “sportswashing”. That focus is only likely to increase as they strengthen further before taking to the European stage, but head coach Howe has insisted his mission will not be derailed as a result. He said: “We’ve been used to that from day one, to be honest. There’s been that feeling that popularity-wise, I don’t think we’re high up on people’s lists for various reasons. “You accept that, I’ve got no issue with that and almost we’ve tried to use that for our benefit and for our gain, really. “I’ve said we’re not here to be popular, we don’t care, really, about outside opinion. We very much care about inside opinion, we care about what the people of Newcastle think of us and what our supporters think. “We’ve tried to act in the right way and make them proud, that’s been our biggest focus.” Newcastle will bring down the curtain on a season which has delivered far more than they might have expected back in August at Chelsea on Sunday, where they will face a club which has spent around £600million since Todd Boehly completed his takeover last summer, but will end the campaign in the bottom half of the table. That tends to suggest that money alone is not the key to success, and the way Howe has blended his new arrivals with the players he inherited and has since improved markedly has been equally, if not more important. Asked if he regretted the focus on finance, the 45-year-old said: “I don’t really take it personally as in my achievement because it’s not really my achievement, it’s the achievement of the players who have committed to this season and what they’ve given. That would hurt me for them. I've said many times sitting here, it's not about money. Newcastle head coach Eddie Howe “I think the players deserve huge credit individually for some of the seasons that they’ve delivered and collectively for what they’ve done. “I’ve said many times sitting here, it’s not about money. Money has played a part, it’s been a contributing factor, of course it has. “But we’ve seen teams up and down the Premier League spend similar amounts of money and not have the success and not be as consistent as we have.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Liverpool’s lack of final-day drama ‘completely new’ to boss Jurgen Klopp Frank Lampard will be ‘back at Chelsea many times’ as a fan after interim role Ruben Selles urges Southampton to end wretched season on positive note

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