Sage Therapeutics said on Thursday it would cut its workforce by about 40%, weeks after the U.S. health

Rex Heuermann left his office near the Empire State Building and strolled down a still-bustling Fifth Avenue as the sun set on a hot Thursday evening in Manhattan.

Harry Kane put the uncertainty over his future to one side to score four times in Tottenham’s 5-1 pre-season friendly win over Shakhtar Donetsk. Kane has been the subject of interest from Bayern Munich all summer and the German club are reported to have lodged their latest bid for the forward on Friday. An apparent self-imposed deadline of midnight was also set by Bayern, but there has been no further news on the outcome of that bid and Kane showed no signs that he was distracted by grabbing a hat-trick in 55 minutes against Shakhtar while being continuously serenaded by the home crowd. Sunday’s fixture was new boss Ange Postecoglou’s first match at Tottenham Hotspur Stadium and he was introduced before kick-off to strong applause. The decibel level were raised even more when Kane’s name was announced after he was included in the starting line-up and given the captain’s armband in the absence of Hugo Lloris. After Kane had two early shots saved, he scored the first of his four-goal salvo in the 38th-minute when he fired home from the penalty spot after James Maddison had been brought down in the area. Shakhtar did level on the verge of half-time when Kevin Kelsy headed in from close-range, but it was soon back to the Kane show. Maddison again combined with his England team-mate in the 50th-minute when his floated crossed was nodded in at the back post by Kane. The hat-trick was completed five minutes later when Son passed into Dejan Kulusevski, who slipped the ball between Mykola Matviyenko’s legs and Kane drilled into the bottom corner. Spurs’ record goal-scorer had already heard several renditions of ‘he’s one of our own’ before his treble but a section of the South Stand chanted ‘we want you to stay’ after his third goal. There was still time for one more Kane goal when substitute Manor Solomon saw his curled shot saved and Kane was there to tap in from close-range in the 79th-minute. Postecoglou replaced the forward a minute later and Kane left the pitch to a standing ovation before he responded with applause to all four corners of the ground. Academy graduate Dane Scarlett replaced Kane and scored with the last kick of the game with a fine left-footed effort from Kulusevski’s cross. The full-time whistle followed and Kane walked over on his own to each side of the stadium to clap the fans still in attendance in what Tottenham supporters will hope is not the last time they have seen their all-time leading goal-scorer. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Leicestershire-born Ashleigh Plumptre out to beat England at Women’s World Cup Dozens of triathletes stuck down with diarrhoea and vomiting after ‘swimming in s**t’ Finn Russell expects different challenge from full-strength France next week

The FA confirm they will review the investigation into Tottenham's sale of Jermain Defoe in 2008 amid claims Spurs used an unlicensed agent.

Work has resumed at a precious metals mine in south-central Montana a day after an Idaho man died in an underground machinery accident

Matthew Perry’s character from Friends, Chandler Bing, was so beloved by millions that the actor will forever be associated with him and his hilarious one liners. But Perry, who died on 28 October in Los Angeles, wasn’t just a one-trick pony. He was in dozens of films, TV shows and even stage productions that show his legacy is far richer and more varied than just being remembered for the famous sitcom. Here are a couple of his lesser known works, in celebration of Perry's life and career. She’s Out Of Control (1989) Chandler wasn’t even a glint in Perry’s eye when he appeared in Stan Dragoti’s 1989 indie comedy She’s Out Of Control. The coming of age comedy starring Tony Danza and Catherine Hicks is about a father coming to terms with his daughter growing up. A twenty-year-old Perry played Timothy, one of the daughter’s several boyfriends in the film. Unfortunately, it didn’t go down well with the critics. One reviewer wrote: “I became so depressed I actually thought about quitting my job as a film critic.” But 34 years later, the film has a certain charm and certainly carries a few laughs. For diehard fans of Friends it is required viewing. Matthew Perry in She's Out of Control (1989) www.youtube.com The Odd Couple (2015-17) Perry executive produced The Odd Couple, a sitcom based on the 1965 play written by Neil Simon. He also starred in it as the slovenly Oscar Madison, acting opposite Thomas Lennon playing the obsessively tidy Felix Unger. In fact, Perry had been pushing for a version of the show to be made since the late noughties, hoping for a launch in 2010. However, executives passed on it, and Perry was forced to shop it around. Eventually, it got picked up in 2013, and Perry got his show. It ran for 38 episodes across three seasons, marking Perry’s longest-running TV show behind Friends. The Odd Couple Episode 1 01 Pilot Sneak Peek 3 www.youtube.com The End Of Longing (2016) Perry’s stage career wasn’t as extensive as his film and TV appearances, but he still found time to write his own play. The End Of Longing was a dark comedy, starring Perry as an alcoholic named Jack, and was performed both on Broadway and on the West End. Referencing his own struggles with addiction, Perry later wrote that the play was “sort of an exaggerated form of myself” but that it was not an autobiographical part. While it got mixed reviews, one critic said: “The writing is wired, raw, politically incorrect and very funny [...] Perry's a novice playwright, but one of great promise.” Matthew Perry on His Play 'The End of Longing' www.youtube.com The Whole Nine Yards (2000) Being at the peak of his Friends fame didn’t stop Perry from appearing in The Whole Nine Yards, a crime comedy starring Bruce Willis. Perry plays Oz, a mild-mannered dentist who travels to Chicago to inform a mob boss about the whereabouts of his new neighbour, a former hitman with a price on his head. Film critic Roger Ebert wrote: “A subtle but unmistakable aura of jolliness sneaks from the screen during The Whole Nine Yards, and eventually we suspect that the actors are barely suppressing giggles. “This is the kind of standard material everyone could do in lockstep, but you sense inner smiles, and you suspect the actors are enjoying themselves.” It’s a romp, and well worth a watch. The Whole Nine Yards (2000) Official Trailer - Bruce Willis, Matthew Perry Movie HD www.youtube.com Serving Sara (2002) Perry didn’t do quite so well in Serving Sara, the romcom starring him and Elizabeth Hurley. The film follows a server given the assignment to serve a British socialite with divorce papers. However, he is bribed to serve her husband instead so that she can get a big divorce payout – and all manner of chaos ensues. Sadly, the film was thoroughly panned and didn’t do well at the box office, where it grossed only $5.8m on opening weekend. Check out the trailer and judge for yourself. Serving Sara Trailer www.youtube.com Scrubs (2004) And finally, from one era-defining sitcom to another, Perry went from Friends to a guest appearance in Scrubs. The medical comedy, which starred Zach Braff, went on for nine seasons through the noughties, and became one of the best-loved shows of its era. Perry played an air traffic controller, Murray. See a clip of Perry and Braff, the comic duo you didn’t know you needed, here. Scrubs - Matthew Perry In Scrubs - Aeroplane www.youtube.com Sign up for our free Indy100 weekly newsletter How to join the indy100's free WhatsApp channel Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings

Claims of vote rigging and election fraud are spreading in Spain ahead of that nation's pivotal election on Sunday

Wolves have moved swiftly to install Gary O’Neil as Julen Lopetegui’s replacement as head coach. The 40-year-old, the club’s first British coach in six years, was sacked by Bournemouth in June despite guiding the Cherries to survival. He has signed a three-year deal after Wolves and Lopetegui came to an “agreement to part ways” on Tuesday after disagreements over recruitment and the direction of the club. “We’re delighted to welcome Gary to the club,” said sporting director Matt Hobbs. “He’s a highly-motivated young coach with strong principles and very well thought of by everyone he has worked with, and we’re excited to see what we can achieve together at Wolves. “Our players have shown their quality during pre-season, and I believe Gary and his team will continue to coach and improve them and will have success working with this group. “Everyone at Wolves is looking forward to welcoming Gary, offering him their full support and working collaboratively to help the club to keep pushing forward together.” With just a couple of days until the Premier League season kicks off O’Neil’s first match in charge will be against Manchester United at Old Trafford on Monday. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live

Rishi Sunak says a new defence partnership will see closer co-operation between the armed forces.

Former President Donald Trump praised a judge he appointed as he awaits to hear about his request to delay the trial in the classified documents case until after the 2024 election. “I know it’s a very highly respected judge. A very smart judge, and a very strong judge,” Mr Trump said on Fox News’ Sunday Morning Futures, referring to federal Judge Aileen Cannon. Judge Cannon also presided over the court proceedings surrounding the FBI search of Mar-a-Lago. Host Maria Bartiromo pointed out that the federal judge was appointed by Mr Trump. He replied, “I did, and I’m very proud to have appointed her.” “But she’s very smart and very strong, and loves our country,” the former president continued. “We need judges that love our country so they do the right thing.” Attorneys for Mr Trump — and his co-defendent Walt Nauta — wrote in a filing on Monday: “Proceeding to trial during the pendency of a Presidential election cycle wherein opposing candidates are effectively (if not literally) directly adverse to one another in this action will create extraordinary challenges in the jury selection process and limit the Defendants’ ability to secure a fair and impartial adjudication.” Last month Mr Trump pleaded not guilty to the 37 count federal indictment in the classified documents case, which is led by Special Counsel Jack Smith. Judge Cannon was criticised last year when she issued what many legal experts saw as an unusually broad decision to appoint a “special master” to review the documents seized by the FBI from Mr Trump’s home. She temporarily barred federal agents and prosecutors from reviewing a batch of classified documents seized during the search. However, her order was ultimately thrown out in a scathing opinion by a federal appeals court, which found she had overstepped. While Mr Trump’s supporters had cheered her ruling as a check on what they viewed as a politically motivated probe, others accused her of trying to help the former president. With reporting from the Associated Press Read More Is DeSantis campaign dead in the water? The money says yes Donald Trump Jr says he wouldn’t have got away with having cocaine at White House: ‘Luckily it’s not my thing’ Fox News anchor and Trump superfan Maria Bartiromo shocks by pushing back on ex-president: ‘You didn’t drain the swamp’

Whether born of folklore or a historical tragedy, each of these ladies has a haunting tale.

Prices for Arizona Diamondbacks tickets are surprisingly low, which isn't a good sign for team morale heading into Games 3, 4 and 5.