By Ankur Banerjee SINGAPORE The U.S. dollar was subdued on Tuesday as traders resisted placing large bets ahead

Women with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) tend to have more symptoms and co-occurring conditions than men, according to the world’s largest study of the disease. The study, entitled DecodeME, reveals women who have the condition for more than 10 years are more likely to experience increasingly severe symptoms as they get older. ME/CFS is estimated to affect more than 250,000 people in the UK, of all ages and from all social and economic backgrounds. Its key feature, called post-exertional malaise, is a delayed dramatic worsening of symptoms following minor physical effort. Other symptoms include pain, brain fog and extreme energy limitation that does not improve with rest. Causes are unknown and there is currently no diagnostic test or cure. Experts from the University of Edinburgh analysed anonymous survey questionnaires from more than 17,000 people with ME/CFS. Two-thirds of women, and slightly more than half of men, reported at least one active co-occurring condition. Similarly, 39.2% of women and 28.6% of men reported at least one inactive co-occurring condition. We discovered that the disease is worse for women, in older people, and many years after their ME/CFS started Professor Chris Ponting of the University of Edinburgh A condition was considered active if the participant had experienced symptoms in the preceding six months. The most common active co-occurring condition was irritable bowel syndrome, with clinical depression, fibromyalgia, anaemia and hypothyroidism also featuring prominently. Women also reported, on average, more symptoms than men – 42 compared with 36. The most common of these symptoms were brain fog – a term commonly used to describe the cognitive impairment experienced by participants – unrefreshing sleep and muscle pain. These findings highlight the very serious impact ME/CFS has on women who are disproportionately affected Sonya Chowdhury, chief executive of Action for M.E Participants were also asked to define the severity of their illness from mild to very severe using definitions from the UK’s National Institute for Health and Care Excellence guidelines. Experts identified that being a woman and having ME/CFS for more than 10 years are risk factors for severe illness, with symptoms increasing in intensity as they age. Professor Chris Ponting, study lead from the MRC human genetics unit at the University of Edinburgh’s Institute of Genetics and Cancer, said: “ME/CFS is a devastating disease affecting a UK population the size of Derby. “We discovered that the disease is worse for women, in older people, and many years after their ME/CFS started. “Our hope is that DecodeME’s genetic results will shed light on why certain groups are more susceptible to ME/CFS than others.” Sonya Chowdhury, chief executive of Action for M.E. and chair of the management group of the study, said: “These findings highlight the very serious impact ME/CFS has on women who are disproportionately affected. “It’s important to also recognise the impact that it has on men who have ME/CFS and we thank the 20,000 men and women who have already signed up to take part in this very important study. “We still need more to join us, so if you are 16 or older, live in the UK and have a diagnosis of ME/CFS, please do take part now to help us decode ME at www.decodeme.org.uk/portal.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live 4 hacks to get teens off the sofa and get active – as study warns of heart damage Taking adult education classes may lower risk of dementia, study suggests Indiyah Polack: I didn’t want to go on Love Island because of my acne

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Kylian Mbappe snatched a famous Champions League victory from Newcastle’s grasp with a controversial penalty in the eighth minute of stoppage-time to earn Paris St Germain a 1-1 draw at the Parc des Princes. Defender Tino Livramento was harshly adjudged to have handled Ousmane Dembele’s cross to allow the France superstar to finally beat goalkeeper Nick Pope from the spot on a night when Eddie Howe’s men came within seconds of a win which would have set them up perfectly for their final Group F fixture against AC Milan at St James’ Park. They led through Alexander Isak’s 24th-minute strike and looked to have survived a second-half onslaught with Pope saving from Mbappe, Dembele and substitute Bradley Barcola, but they headed back to Tyneside wondering what might have been after the draw kept their hopes of a place in the last 16 alive, but only just. Victory over the Italians combined with defeat for PSG at Borussia Dortmund, who have already qualified, would see the dream realised, but their fate is now out of their own hands. That is harsh on Howe’s injury-ravaged squad, who turned in a performance of real character in Paris with Bruno Guimaraes Livramento, Pope, Miguel Almiron and – as the game became increasingly stretched – Anthony Gordon shining in particular. Mbappe started in ominous mood as he and Lee Kang-in combined repeatedly down the left and Pope had to save the PSG skipper’s audacious flick with his feet after Randal Kolo Muani had played full-back Achraf Hakimi into space with an equally deft touch. However, the visitors should have taken a 12th-minute lead when Almiron dispossessed Hakimi and crossed low to Isak at the near post only to see the striker lift his first-time shot agonisingly over. They did with 24 minutes gone when full-back Livramento embarked on a scything run which took him past Dembele, Hakimi, Fabian Ruiz, Milan Skriniar, Manuel Ugarte and Lee before he fed Almiron on the right. The Paraguay international curled a shot towards the far post, where goalkeeper Gianluigi Donnarumma could only push the ball out to Isak, who gleefully slammed it into the net. Pope had to come to Isak’s rescue after he lost possession and Dembele raced away and tried to steer the ball inside the far post as PSG responded, but for all their attacking flair, the French side were struggling to break down their English opponents. Skriniar was perhaps fortunate not to be penalised for handball as he made a last-ditch attempt to deny Isak a clear run on goal in stoppage-time, but Pope was grateful for the sizeable presence of Fabian Schar in front of him to keep out Dembele’s well-struck attempt from Mbappe’s cross. Isak was almost through on goal again within seconds of the restart after running on to Joelinton’s defence-splitting pass before eventually being snuffed out by the recovering blue shirts and, with Anthony Gordon keeping the PSG defence occupied, frustration was mounting among the home ranks. They might have been back in it, however, had Pope not raced from his line to block Dembele’s 56th-minute toe-poke and the keeper was rewarded when Mbappe completely missed his as he attempted to acrobatically volley home the rebound. The Magpies edged ever deeper as Luis Enrique’s men fought desperately for a way back into the game and they almost got it with 66 minutes gone when Mbappe tricked his way past Schar and crossed for Barcola, whose point-blank effort was brilliantly saved by Pope. Barcola fired wastefully into the side-netting after getting in behind the visitors’ defence and Gordon survived a VAR review for a penalty after Hakimi had gone down under his challenge with Newcastle visibly tiring. Pope blocked Mbappe’s 87th-minute strike at his near post and saw the France international thump the rebound inches wide, but he was finally beaten at the death after Polish referee Szymon Marciniak had reviewed the incident in which Dembele’s cross appeared to hit Livramento’s side and loop up on to the underside of his arm and belatedly awarded a spot-kick. Read More Newcastle must show ‘top team attitudes’ to beat PSG, says Nick Pope Rumours: Sancho and Antony head up Man Utd’s 15-player sale list PSG vs Newcastle LIVE: Champions League result and reaction PSG vs Newcastle LIVE: Champions League result and reaction As Man City celebrated their past, Phil Foden reminded them of their glorious present Late heartbreak for Newcastle and Manchester City march on in Champions League

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