By Deena Beasley (Reuters) -In a mid-stage trial, the highest dose of Eli Lilly's experimental pill orforglipron led to 14.7%

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Seal has spoken about his close relationship with his and his ex-wife Heidi Klum’s 19-year-old daughter, Leni Olum Klum. The musician, 60, took to Instagram on 4 September to share a snap of him and his daughter in New York City together. In the caption, he described how Leni has ultimately shaped his life, and pointed out how grateful he was for her. “In NY with the young woman who changed my life for the better 19yrs ago. Thank you Leni for making me a better person,” he wrote, before signing the tribute with: “Love you, - papa.” In the comments, Leni expressed her love for her father’s post, writing: “So cute! I love you papa,” along with a red heart emoji. Many fans of the singer went to the comments to praise his sweet relationship with Leni. “So much love in this photo! Have a wonderful time together!” one wrote, while another added: “Daddy and Daughter. Beautiful!!” The young model was born in May 2004, right after Klum split from Leni’s biological father, Italian businessman Flavio Briatore. In December 2009, Seal legally adopted Leni when she was five years old, while the singer and supermodel were still married. The former couple went on to have three more children: sons Henry, 17, and Johan, 16; and daughter Lou, 13. Klum filed for divorce in April 2012. This isn’t the first time that Seal has shown his support for the 19-year-old. During an interview with E! News in March, he spoke out about Leni’s career, as she has followed in her mother’s footsteps by becoming a model. While he noted that he’s “so proud of everything that Leni has done”, he’s “more proud of everything that she is”. “She walks through life with this type of humility that allows her to move so gracefully through it all and she has an innate understanding of people in general and people’s feelings,” the singer explained. “So I’m kind of more impressed with everything that she is.” Seal - whose real name is Seal Henry Olusegun Olumide Adeola Samuel - also spoke candidly about co-parenting with his ex-wife, adding: “I’d like to think, as a parent, that we have - between her mother and myself - that we’ve instilled some of that in her. But she can do no wrong in my eyes and she’s quite wonderful.” Earlier this year, Klum applauded her daughter for working on her mode;ling career while studying in college. “I’m very proud of my daughter and her modelling. And she’s studying at the same time, she’s juggling already,” the America’s Got Talent judge said during an interview with People in March. Meanwhile, Leni has also spoken out about working in the modelling industry as the child of two famous parents. During an interview with People in October 2022, she acknowledged that she “got a lift into” the modelling world due to her upbringing. “It’s just a fact. My parents are famous,” she said. However, when she was asked about the infamous “nepotism baby” label given to children of celebrities, Leni said it’s her own work ethic that has helped build her career thus far. “I did get help starting off, and I know that people would dream to start off with what I had,” the college student explained. “I’m so grateful that I’ve been able to take what was gifted to me by my mom. But I am doing the work and putting in the time. Now I’m working on my own, travelling alone, going to school. My mom and I just have the same love for the same thing.” Although she said that her own ambition has led her to success in her career, she still credited her parents for instilling a strong work ethic in her at a young age. “They have both taught me to be myself, and to do what makes me feel comfortable,” she said. “You can tell if you’re not comfortable and then the best of you isn’t brought out. I just think you should be open and honest with what makes you comfortable, be yourself, do what you love.” Read More Heidi Klum opens up about her and husband Tom Kaulitz’s 16-year age gap Heidi Klum’s model daughter Leni shows off grisly burn after admitting she ‘didn’t use enough sunscreen’ Heidi Klum gushes with pride over daughter Leni for ‘juggling’ modelling and college Heidi Klum denies she counts calories after report she eats 900 calories a day Sleeping pill could reduce levels of Alzheimer’s proteins Marathon runners on why autumn is the best time to start running

The emergence of a Chicago Cubs player could have them thinking about opportunities to trade a star who has rebuilt his name.Don't look now, but the Chicago Cubs might be on their way to the top of the NL Central. That's not to say that, even if they make it there, they'll be very...

Fernando Alonso has hailed Max Verstappen as Formula One’s best driver since Michael Schumacher – with the Dutchman on the brink of clinching his third world crown. The 26-year-old needs to score only three points in Saturday’s sprint race in Qatar to complete a hat-trick of world titles. Lewis Hamilton has won a record 103 races and stands on seven world titles with Schumacher. But Alonso, 42, omitted the British driver when asked if Verstappen must now be ranked alongside the sport’s modern-day greats. “I’ve only been wheel-to-wheel with Michael, but with Michael maybe, yes,” said the double world champion. “And for the next few years he will keep adding championships so we will compare him with Michael even closer in the future.” Following a Red Bull blip in Singapore, Verstappen returned to his all-conquering best at the last round in Japan to take his 13th win from the 16 rounds staged so far. Since Verstappen claimed his maiden title, at Hamilton’s expense, at the controversial season-ending Abu Dhabi race in 2021, Verstappen has won 28 of the 38 races staged – including a record run of 10 straight victories earlier this year. Hamilton, third in the championship in his Mercedes and 210 points adrift of Verstappen, said: “I wouldn’t rank him because ranking people is an opinion-based thing. “But he has earned his position, and he has done an amazing job with the package he has. Him and the team have been phenomenal and faultless this year. “They have raised the bar and as a team we have to look at that, and look at the areas where we can be better and match that and compete. “I do hope at some stage we can fight them and have them defending, but they should enjoy the moment because they have worked for it.” Verstappen will be the first driver to clinch the championship in a sprint race if he finishes sixth or higher in Saturday’s 19-lap dash at the Lusail International Circuit. He will become the 11th driver to have won more than two world titles, emulating the likes of Sir Jackie Stewart and Ayrton Senna with three. His dominance has been compared to Schumacher’s stranglehold on the sport at the turn of the century. Verstappen said: “Michael’s achievements were incredible, but when he was achieving these kind of things it was seen as normal because it was an amazing driver with an amazing team and everything came together. Maybe people got bored of it? But it was incredible to have achieved those kind of things. “I don’t think about reaching seven. We will see year-by-year what happens, but I am very proud. I live in the moment and I want to achieve more. “I know when I stop racing I will be able to look back and I will be able to appreciate it more but it wasn’t something I ever thought was achievable when I was a little kid.” Read More Max Verstappen pips Oscar Piastri to pole after tense qualifying for Japanese GP Lando Norris narrows gap on Max Verstappen at final practice in Japan Max Verstappen returns to form in Japanese Grand Prix practice Aston Martin boss reacts to Andretti’s bid to become 11th F1 team How can Max Verstappen win 2023 F1 world championship in Qatar? British F2 star to make F1 debut with Haas