Rex Heuermann is facing murder charges of three women, all of whom were in their 20s, had a petite body, and worked as sex workers on Craigslist

By Bianca Flowers and Priyamvada C (Reuters) -Tighter lending standards from regional banks are making it harder for U.S. hotel

By Felix Njini and Tiemoko Diallo NAIROBI Some of Mali's top gold producers said a new law to

In the wake of the uprising by Wagner Group forces in Russia, the US and Europe have turned their gaze to an increasingly unpredictable Belarus -- a key Russian ally that Western officials fear could give the exiled mercenary troops a new home and serve as a staging ground for Russian nuclear weapons.

Liam Hendriks has been activated by the Chicago White Sox, clearing another hurdle in his return from non-Hodgkin lymphoma

Dubai used to be a place where the best restaurants had been imported from other parts of the

Sepsis is an illness that affects nearly 50 million people worldwide each year, with around 11 million deaths attributed to the condition. In the United States, at least 1.7 million adults in the US develop sepsis annually, and nearly 270,000 die as a result, the Centres for Disease Control and Prevention (CDC) says. It affects 245,000 people in the UK each year, with around 48,000 deaths, according to the UK Sepsis Trust. World Sepsis Day commemorated on 13th September every year, strives to raise global awareness of the life-threatening condition. The day is seen as “an opportunity for people worldwide to unite in the fight against sepsis,” the Global Sepsis Alliance says. Here is everything you need to know about sepsis: What is sepsis? Sepsis Research says when the condition strikes, the immune system “overreacts” and begins to attack the infection and everything else around it “including the body’s own tissues and organs.” “Any type of infection — bacterial, viral or fungal — can lead to sepsis,” it adds. When sepsis occurs, it can cause inflammation and cause blood clotting around the body, if it does not get treated, it can result in death, organ failure and tissue damage, CDC says. Sepsis cannot be caught from another person, the NHS explains. What are the symptoms? The World Health Organisation (WHO) explains that the condition is a “medical emergency,” so if you think a person is exhibiting signs of sepsis or if you are showing signs – make sure you call 999 or go to the emergency room immediately. According to WHO, common signs and symptoms include: • Fever or low temperature and shivering • Confusion • Difficulty breathing • Clammy or sweaty skin • Extreme body pain or discomfort • High heart rate, weak pulse or low blood pressure • Low urine output Symptoms in children include: • Fast breathing • Convulsions • Pale skin • Lethargy • Difficulty waking up • Feeling cold to touch What are the causes? The Mayo Clinic says any type of infection can lead to sepsis and those that more commonly cause the condition include infections of: • Lungs, such as pneumonia • Kidney, bladder and other parts of the urinary system • Digestive system • Bloodstream • Catheter sites • Wounds or burns “Sepsis often presents as the clinical deterioration of common and preventable infections such as those of the respiratory, gastrointestinal and urinary tract, or of wounds and skin. Sepsis is frequently under-diagnosed at an early stage - when it still is potentially reversible,” the Global Sepsis Alliance says. Who is most at risk? The people most at risk of the condition, according to Mayo Clinic, are: • People with lower immune response, such as those being treated for cancer • People with human immunodeficiency virus (HIV). • People with chronic diseases such as diabetes kidney disease or chronic obstructive pulmonary disease (COPD). • people who are in intensive care or longer hospital stays. • People over the age of 65 • Infants How many cases are there globally? The WHO says a scientific publication estimated that in 2017 there were 48.9 million cases and 11 million sepsis-related deaths worldwide, which accounted for almost 20 per cent of all global deaths. That same year, almost half of all global sepsis cases occurred among children with an estimated 20 million cases and 2.9 million global deaths in children under 5 years of age. How can it be prevented? The Global Sepsis Alliance says the best to to avoid sepsis is by preventing infection. This can be done by undergoing vaccinations, ensuring that you only come into contact with clean water, washing your hands properly and if you are giving birth - making sure it is in a clean and sterilised environment. Can sepsis be treated? Sepsis can be treated with appropriate treatment such as antibiotics – this should be given as soon as possible. The CDC says sometimes “surgery is required to remove tissue damaged by the infection”. “Antibiotics are critical tools for treating life-threatening infections, like those that can lead to sepsis,” the CDC adds. Read More 5 things everyone needs to know about eczema 13 potential cancer symptoms you should get checked out How can I improve my teenager’s low mood? Duran Duran’s Andy Taylor says he’s ‘asymptomatic’ after end-of-life diagnosis Nine hours of parallel surgery: how Britain’s first womb transplant was carried out Bursts of activity that make you huff and puff ‘linked to reduced cancer risk’

The Big Ten feels more like the Big Three this season

Indiana Jones and Harrison Ford will swing into Cannes on Thursday for the world premiere of “Indiana Jones and the Dial of Destiny” in one of the most anticipated events of the French Riviera festival

Britney Spears revealed she was "glad" to have lost the lead role in The Notebook to Rachel McAdams, prompting casting director Matthew Barry to share her audition tape with The Daily Mail. In the two-minute long video, Spears says, whilst her eyes well up with tears, "I prayed for you to die in the war, really. Well, not die. I would have felt completely horrible if you would've died. But I kinda didn't want you to be alive anymore because I couldn't bear the thought of you being with somebody else, or of us never seeing each other again. So I gotta go, okay?" Barry told The Daily Mail the pop star "wasn't just good, she was phenomenal." "It was a tough decision," he continued, reflecting on Spears' audition. "Britney blew us all away. Our jaws were on the floor. I was blown away. Absolutely blown away. She brought her A-game that day." Since the sharing of Spears' audition, people have praised her acting but ultimately agreed that it should have been McAdams that got the part. "Love Britney down and she looked adorable but Rachel McAdams was just born for the role", the top comment under the tape read: "I mean [obviously] Rachel is perfect in this role, but I'm actually really impressed with [Britney's] audition", wrote another. This sentiment was prevalent throughout the reactions to Spears' tape. "Rachel was perfect and iconic for the role. HOWEVER... seeing this I now understand why Britney was considered for the role", one user shared. It seems Spears agrees that role should have gone to McAdams, writing in her upcoming memoir The Woman in Me "Even though it would have been fun to reconnect with Ryan Gosling after our time on The Mickey Mouse Club, I'm glad I didn't do it," she writes. "If I had, instead of working on my album 'In the Zone' I'd have been acting like a 1940s heiress day and night." Sign up to our free Indy100 weekly newsletter How to join the indy100's free WhatsApp channel Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

It took two full days for Israel to clear Hamas fighters from its land - and some are asking why.

Jonnie Irwin has opened up about why he hasn’t told his three children that he has terminal cancer. The A Place in the Sun presenter, 49, publicly revealed his diagnosis in November 2022 after his lung cancer spread to his brain. However, his young sons, who he shares with wife Jessica Holmes, do not know that their father is dying. Irwin says it would be difficult for them to understand his situation at this age: his eldest son Rex is four-and-a-half, while twins Rafa and Cormac are turning three this month. In a new interview with Hello! magazine ahead of Father’s Day, Irwin said: “I keep being asked, ‘Are you going to tell them?’ but tell them what? “It would be horrible news that they’d have to get their heads around. And it would confuse the hell out of Rex – he’s got a shocking enough day coming. Let’s bury our heads in the sand for as long as possible.” In the meantime, Irwin and Holmes are trying to give their children a sense of normalcy by continuing to teach and play with them. Holmes described the presenter as a “great dad and a big kid himself”, adding: “All the boys gravitate to him when they want to show off and get his attention. They’re aware that Jonnie needs his rest and can’t always jump up and play football for hours, but they’re more than happy snuggled up on the sofa, watching a movie. “Story time is a big thing at bedtime and that is something I know Jonnie treasures with them.” In November, when Irwin first revealed his diagnosis, he said Rex “doesn’t need to know” about his illness yet. “We make fun of my hair – he calls it my ‘spiky head’ – but as far as he’s concerned, his dad is normal and why would I shatter that innocence?” Earlier this month, Irwin was admitted to hospital to be “monitored” as his treatment continues. He shared in an Instagram post that he was admitted to keep an eye on a “changeover in my pain management regime”. In an appearance on the OneChat podcast by insurer AIG Life, Irwin said he had been close to dying “at least twice”. “You lose your memory, you lose your patience. I have got a very short temper. It’s not made me a better person, that’s for sure,” he admitted. However, Irwin emphasised that he prefers to think of his situation as “living with cancer, rather than dying from cancer”. Read More A Place In The Sun’s Jonnie Irwin admitted to hospital amid terminal diagnosis Jonnie Irwin says he’s been ‘close to death’s door twice, at least’ Jonnie Irwin says going public with terminal cancer diagnosis was day he began ‘living again’