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One of the scientists whose work pioneered the development of medications such as Ozempic and Wegovy has revealed why life may become “so miserably boring” after two years of using the drug. Ozempic is an FDA-approved medication used for the treatment of type 2 diabetes. It works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), which regulates blood sugar levels and slows down the rate at which food leaves the stomach, often creating the feeling of fullness. These semaglutide injections – sold under the brand names Ozempic and Wegovy – have soared in popularity as many people, including Hollywood celebrities, have used it for weight loss. What’s more, people have also found Ozempic has been effective in curing their addictive habits, like drinking, smoking, shopping, or nail biting. However, because of Ozempic’s increasing popularity, it has led to national shortages of the type 2 diabetes treatment – leaving those who actually need it without. In an interview with Wired, professor Jens Juul Holst – who received the Warren Alpert Foundation Prize in 2021 for his work developing treatments based on the GLP-1 hormone – spoke about the effects of Ozempic, and why he believes many people will stop taking the medication after just a few years. “What happens is that you lose your appetite and also the pleasure of eating, and so I think there’s a price to be paid when you do that,” Holst told Wired. “If you like food, then that pleasure is gone. The craving for food for some people is taken away when they take GLP-1 drugs.” He continued: “That may eventually be a problem, that once you’ve been on this for a year or two, life is so miserably boring that you can’t stand it any longer and you have to go back to your old life.” Holst added that medications like Ozempic and Wegovy have been on the market since 2005, though studies show that these people don’t stay on them for very long. “It’s just like every other drug, they don’t stay on it for many reasons,” he explained. “One of the reasons, as I said, is that once you have tried it and you realise you’ve lost interest in food, then that may be enough.” “We don’t know why people stop taking these drugs, but we know for a fact that they do stop. They do that all over the world.” A 2020 study found that 70 per cent of people who took GLP-1 drugs for type 2 diabetes stopped taking them within two years. However, this could pose a problem for many patients taking semaglutide injections. Research has found that people who stopped taking Ozempic or Wegovy for weight loss experienced weight rebound. A trial published in April 2022 saw participants gain back two thirds of the weight they had lost after 68 weeks of taking semaglutide. As for celebrities who use the once-weekly injection for weight loss, despite not having diabetes or clinical obesity, Hans instead called attention to the “many terrible problems” that those with diabetes have struggled with by not having drugs like Ozempic readily available. “Have you ever visited a diabetes hospital? It’s really deplorable,” he said. “People come in with amputated limbs and compromised cognitive functions and heart problems or they can barely move – they’re miserable and depressed. It’s really serious. There is so much you can improve with a drug that is not only a weight-loss drug but is also an anti-diabetic.” Amidst the popularity of semaglutide injections, the US Food and Drug Administration has issued warnings for consumers not to use off-brand versions of Ozempic or Wegovy, because they may not include the same GLP-1 hormone used in approved medications. Earlier this month, agency officials reported problems with patients using compounded versions of semaglutide – which combines traditional semaglutide with other ingredients. These drugs are not FDA-approved, and the agency does not verify the safety or effectiveness of compounded drugs. Consumers should only use drugs containing semaglutide with a prescription from a licensed health care provider and obtained from a state-licensed pharmacy or other facilities registered with the FDA, the agency said. Read More What is ‘Ozempic face’? Doctors warn about facial ageing side effect of diabetes medications How does Wegovy work? The ‘game changing’ weight loss drug beloved by Hollywood FDA warns against using off-brand versions of Ozempic, Wegovy for weight loss Scientist behind Ozempic says drug can make life ‘so miserably boring’ Pregnant Stassi Schroeder admits she wants to ‘try’ Ozempic after giving birth Doctors warn about ‘Ozempic face’ side effect of medications

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Marc Guehi is aiming to be England’s ‘Steady Eddie’ after overcoming doubts during a loan stint at Swansea to become a regular in Gareth Southgate’s squad. The Crystal Palace centre-back, 23, has seven senior caps and has featured in three of the previous four games ahead of the final Euro 2024 qualification double-header against Malta and North Macedonia. Having come through the ranks at Chelsea, where he credits Claude Makelele as a mentor, Guehi never made a Premier League appearance for the Blues but is now a fixture in the division in south London. Guehi was also capped at every England age group from Under-16s upwards until making his senior debut last year. Asked how he has dealt with every step up in his career, Guehi replied: “The trait is, that in my life everything has been quite steady. Growing up I was never pushed on too soon, or left behind. “It was always quite steady and my career has been exactly the same. In the academy, going out on loan, steadily playing game after game and gaining confidence. Getting the move to Palace and finding my feet in the Premier League and now coming here with England. “So when you talk about those steps and progression, everything for me has been quite natural. I just see things how they are and take things how they come. “When I said about the steadiness, along that pathway there is those setbacks. I think it’s your job as an individual to just learn from those as quickly as possible. And not allow them to drag you from behind. “There’s been many setbacks and always will be. It’s about learning from them and using those moments to prove yourself.” The main setback for Guehi was during his time on loan at Swansea, a move which coincided with the start of the coronavirus pandemic that shut down football for over three months during the 2019/20 season. Guehi was away from home and had fallen out of favour in the Swansea team, not featuring in the final four matchday squads before football was halted – although he returned to get back into the side before spending another campaign on loan at the Liberty Stadium. “Not many people know, it was tough for me at Swansea,” he said. Those moments were difficult, you take those moments, learn from them, try to move on and put them right Marc Guehi “I have not spoken about it, everyone thinks it was plain sailing, great. I played the first four games and then I didn’t play up until after lockdown. Being away from home, in Swansea, different country, on your own, there’s going to be challenges, going to be tough. “Those moments were difficult, you take those moments, learn from them, try to move on and put them right. I was just out of favour. Not anything in particular. I came from Chelsea, came with a lot of confidence, and my confidence almost gets knocked. “Thankfully, I did get back home, just in time before (lockdown), it was so strange to say it, for so many people around the world it was horrible, for my family, and so many people around. “For me, it was probably the best moment, I could get away from football, be with my family, and just focus on myself. How can I now if football does come back – thankfully football did come back – if we do get back to playing, how can I get back in this team? “I genuinely enjoyed Swansea. It was good. Swansea was a great place for me to play. I had a great view from an apartment looking out onto the beach although it was not sunny but it was still a decent view.” Guehi, who plays drums at his church when time allows and whose father is a pastor, has used setbacks such as his experiences in south Wales, to build a stronger mentality. “It is like building calluses but in your mind,” he added. “Going through those moments does help you in everyday life, everyday situations. You might have a bad game but you remember what you’ve gone through before, and you almost put that to bed and go I just need to prove myself the next game. Moving steadily.” Read More Anthony Joshua sees Otto Wallin as a stepping stone on his way to a title fight Rohit Sharma glad India ‘could get the job done’ against New Zealand Still plenty to play for – Scotland v Georgia talking points A look at the data behind Virat Kohli’s record 50 ODI centuries Virat Kohli hits record ton as India beat New Zealand to reach World Cup final Francis Ngannou ranked as top-10 heavyweight by WBC after impressive debut

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