TL;DR: A lifetime subscription to a SheetMagic Single User Plan is on sale for £40.54,

Nineteen-year-old Priscila scored a last-minute goal in her women’s national team debut to give Brazil a 4-3 win over Japan in a friendly

Mets infielder Luis Guillorme injured his calf during the first game of New York's day-night doubleheader against the Boston Red Sox

Joe Lewis, the UK billionaire and owner of the Tottenham Hotspur football club, has been indicted in the US for what officials called a “brazen” set of insider trading schemes. “He used inside information as a way to compensate his employees or shower gifts on his friends and lovers,” US Attorney Damian Williams said in a video statement on Tuesday. “That’s classic corporate corruption,” he added. “It’s cheating, and it’s against the law.” The Independent has contacted Tottenham for comment, as well as Tavistock Group, the investment office founded by Mr Lewis. This is a breaking news story and will be updated with new information.

Ishika Bhargava playfully teased IShowSpeed by speaking in Hindi but then seamlessly transitioned into English for the conversation

Expanding government handouts will encourage the child-rearing generation, many of whom say they can’t afford to start a

By Johannes Birkebaek COPENHAGEN Danish dairy firm Arla lowered its full-year sales forecast on Tuesday, saying inflation and

Juan Soto homered twice, including his first career grand slam, and the San Diego Padres won their fourth straight game for the first time this season, beating the Oakland Athletics 10-1

Tesla has reported that its net income slumped in the third quarter versus a year earlier

The Florida Panthers got on the board in Game 3 of the Stanley Cup Final, but will the Vegas Golden Knights strike back in Game 4?This Stanley Cup Final series started with one of the most dominant home performances for a finals team.The Vegas Golden Knights were nothing less than spectacula...

By Wendell Roelf CAPE TOWN Banks and other financiers should withdraw their support of TotalEnergies' $20 billion liquefied

Google says it has made a significant step in identifying disease-causing genes, which could help spot rare genetic disorders. A new model named AlphaMissense is able to confidently classify 89 per cent of all possible “missense” variants in genes, identifying whether they are likely to cause diseases or benign. That compares with just 0.1 per cent of all missense variants that have been confidently classified by human experts. Missense variants happen when a single letter is substituted in the DNA, which in turn leads to proteins with a different amino acid. That small change can have significant effects – Google likened it to the way that changing a letter in one word can change the meaning of the whole sentence. Most of those variants are benign: the average person has more than 9,000 of them. But some of them can be disastrous, leading to rare genetic diseases. The new AlphaMissense looked at existing information about missense variants, and how commonly they are seen in humans and closely-related primates. It looked for those that were rarely seen, classifying them as pathogenic, and from that was able to use that information to analyse other protein sequences – giving not just a verdict on whether they were likely to cause problems, but also how confident it was. Experiments, conducted by humans, which look to find those mutations are expensive and slow: they require people to examine each unique protein and designed separately. Google says that the new system means that researchers can “preview” those results for thousands of proteins at a time, helping them decide where to focus. The company has used its systems to release a vast catalogue of “missense” mutations, so that researchers can learn about what effect they have. In some cases, those variations can lead to conditions such as cystic fibrosis, sickle-cell anaemia, or cancer, and understanding them could be key to researchers studying ways to treat or prevent those diseases. It is just the latest health breakthrough from Google’s Deepmind division, which is looking to use artificial intelligence to both identify and treat a variety of conditions. The new system was built on AlphaFold, the breakthrough model that helped unfold proteins, the building blocks of life. The research is described in a new paper, ‘Accurate proteome-wide missense variant effect prediction with AlphaMissense’, published in the journal Science. The catalogue is being made “freely available to the research community”, Google said, and the company will release the code behind the AI system. Read More BBC removes some Russell Brand content as monetisation suspended on YouTube Google Bard can now link to Gmail and other apps to help with responses Long-form video content is here to stay, says YouTube UK boss