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IRVINE, Calif.--(BUSINESS WIRE)--Aug 31, 2023--

Scientists have grown human kidneys in pigs, for the very first time. Researchers at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences and Wuyi University created human-pig chimeric embryos containing a combination of human and pig cells. When they transferred into 13 surrogate pig mothers, they developed kidneys that contained mostly human cells at a rate of 50 to 60 per cent, giving hope for potential transplants in the future. “Rat organs have been produced in mice, and mouse organs have been produced in rats, but previous attempts to grow human organs in pigs have not succeeded,” said the senior author Liangxue Lai. “Our approach improves the integration of human cells into recipient tissues and allows us to grow human organs in pigs.” The kidneys were not entirely human as they included vasculature and nerves made mostly from pig cells, meaning they could not be used for transplantation in their current form, but it is still a pretty impressive step. And apart from the kidneys, the embryos were dominated by pig cells, with very few human cells in the brain or central nervous system. Making brains using human and pig cells is very controversial for ethical reasons, so there are tight regulations for this kind of research. Meanwhile, pig cells tend to outcompete human cells during development, so previous experiments have created embryos that are almost entirely pig. The latest work, published in Cell Stem Cell, overcame this by genetically engineering a single-cell pig embryo so that it lacked two genes needed for kidney development. This created a gap within the embryo that could be filled by human cells. “We found that if you create a niche in the pig embryo, then the human cells naturally go into these spaces,” said Prof Zhen Dai of Guangzhou Institutes of Biomedicine and Health, another senior author. The scientists said that being able to incubate a fully human kidney inside a pig would be likely to take many years. “We would probably need to engineer the pigs in a much more complex way and that also brings some additional challenges,” said Miguel Esteban, also of the Guangzhou institute and a senior author. A central challenge would be to allow human nerves and vasculature to develop within the target organ without nerve cells developing in the central nervous system that could lead to a humanised brain. “Even theoretically it’s not clear how you’d do that,” said Ilic. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Angelina Jolie has admitted that she’s still trying to figure out what her style is, as she opened up about wanting to look “soft” after being “hurt” in the past. The actor, 48, spoke candidly about her fashion sense during a recent interview with Vogue to discuss her new brand, Atelier Jolie. She began by describing how she believes people perceive her based on the clothes she wears. “Sometimes the way you dress says: ‘Don’t mess with me - I’ve got my armour on,’” she said. “But I want a woman to feel safe enough that she can be soft.” The Maleficent star revealed that when she was faced with a difficult time in her life, she was ultimately encouraged to choose clothes that made her look “soft”. “After I went through something where I was hurt, I had a therapist ask if I would try wearing a flowing garment,” she said. “Sounds silly, but I assumed that pants and boots projected a ‘tougher’ look, a stronger me. But was I strong enough to be soft?” While Jolie confessed that she didn’t feel too strong at time, she acknowledged that she’s still figuring out what her style is - despite being hurt in the past. “I felt vulnerable. Now I wonder if I don’t know what my style is because I’m still understanding who I am at 48. I guess I’m in transition as a person,” she added. The Salt star seemingly alluded to some of the personal challenges she faced over the years, including her split from ex-husband Brad Pitt in 2016. “I feel a bit down these days. I don’t feel like I’ve been myself for a decade, in a way, which I don’t want to get into,” she said. Jolie added that she’s in a place in her film career where she’s “only taking jobs that didn’t require long shoots” after spending the last seven years doing “a lot of healing”. She also noted that while she’s “still finding [her] footing”, her work with her fashion brand has offered her a new perspective. “I think part of this has also been therapeutic for me - to work in a creative space with people you trust and to rediscover yourself,” the actor explained. “I’m hoping to change many aspects of my life. And this is the forward-facing one.” In May, Jolie took to Instagram to announce the launch of Atelier Jolie, which she described as “a collective where everyone can create”. “Atelier Jolie is a place for creative people to collaborate with a skilled and diverse family of expert tailors, pattern makers and artisans from around the world,” she wrote in the caption. “It stems from my appreciation and deep respect for the many tailors and makers I’ve worked with over the years, a desire to make use of the high-quality vintage material and deadstock fabric already available, and also to be part of a movement to cultivate more self-expression.” During her interview with Vogue, the Mr & Mrs Smith star spoke candidly about her new career in the fashion industry, noting that her brand is “not really about fashion”. “I don’t want to be a big fashion designer,” Jolie said. “I want to build a house for other people to become that.” Read More Angelina Jolie says her children ‘saved’ her as she opens up about ‘healing’ after Brad Pitt divorce Salma Hayek reveals what she loves most about her friendship with Angelina Jolie Brad Pitt and Angelina Jolie ‘set to try and resolve’ longrunning vineyard dispute Angelina Jolie says her children ‘saved’ her as she opens up about Brad Pitt divorce Salma Hayek reveals what she loves most about her friendship with Angelina Jolie Sarah Jessica Parker’s custom 2014 Met Gala dress goes up for auction

Canada's Brooke Henderson birdied six of her last nine holes to grab a one-stroke lead when darkness halted first-round play on...