Celebrities having birthdays during the week of July 23-29 include actor-singer Jennifer Lopez, movie director Patty Jenkins and drummer Roger Taylor of Queen

Newcastle United may have had a close-up view of Borussia Dortmund’s two best performances of the season but Eddie Howe rued: “I don’t think Dortmund have seen the best Newcastle.” Paris Saint-Germain have, but that might not be enough to spare his side. The Champions League may not see much more of Newcastle for this season and the group of death might lead to an early autopsy. After Tuesday night’s 2-0 reversal made it twin defeats to Dortmund, Howe conceded Newcastle probably need two wins – away to PSG, at home to AC Milan – to extend their participation beyond Christmas. His downcast air suggested it is unlikely. From topping their pool two weeks earlier, Newcastle prop it up. And there was a death of sorts in the Signal Iduna Park on a night to showcase where, after it went spectacularly right on the night against PSG, it has gone wrong for Newcastle. Callum Wilson had four touches and went off at half-time, Howe citing a tight hamstring, others wondering if an ineffectual performance was the reason. Kieran Trippier, so good for much of the campaign, had a second underwhelming outing against Dortmund, his poor free kick leading to their second goal. Bruno Guimaraes, without Sandro Tonali to share the load, was no better; Newcastle had looked over-reliant on each to conjure something. Lewis Hall’s Champions League debut was curtailed after 45 minutes in which he was booked and because Howe was concerned he might be sent off. Tino Livramento’s bow at this level was more encouraging but he had to play three different positions and Joelinton wasted the chance he made. Anthony Gordon and Miguel Almiron began on the bench, players who are reliant on sharpness suffering from their recent workload, and without Harvey Barnes, Alexander Isak and Jacob Murphy, there were no alternative forwards. The eventual analysis may be that Newcastle were wounded before they suffered a fatal blow. They ran out of players, losing some of those who may have made a difference. Isak played only 14 minutes at home to Dortmund, none away. Barnes has played one minute in the competition. Sven Botman has a lone appearance, and it brought Newcastle’s sole clean sheet. Without Dan Burn, three different players took turns at left-back in the Signal Iduna Park. Injuries have been compounded by another absence, and the prospect of it: but for his impending betting ban, Tonali may have started when Dortmund visited St James’ Park. Their build-up disrupted, that defeat deprived Newcastle of momentum. The Italian was supposed to add Champions League experience. Should the standings stay the same, should Dortmund progress, the knowhow of annual entrants may appear crucial; Newcastle are rookies at this level and Howe did not dispute that his side have not always replicated their domestic form in continental competition. There is a contrast between their fortunes in England and Europe. Edin Terzic had studied the statistics. “We manged to win twice against Newcastle, their only two defeats in 13 matches, every time with a clean sheet,” noted the Dortmund manager. Only Manchester City and Brighton have shut Newcastle out in the Premier League or Carabao Cup; Milan have done once and Dortmund twice in the Champions League. Newcastle have not scored away in Europe. “I think we have had chances in both games,” said Howe. “Maybe haven’t been as clinical as we would like.” Yet they had a lone shot on target in San Siro, from Sean Longstaff in injury time, and if Joelinton was profligate in the Signal Iduna Park, others did not get the opportunity to be. Newcastle felt insufficiently creative. Maybe it would have been different had Gordon been able to set the tone by rousing, riling and rattling. “Anthony played 90 minutes against Arsenal and gave everything,” Howe explained. “The turnaround was too quick for him to start so we wanted to use him as an impact player.” There was reason behind the rotation but it backfired. Yet Dortmund showed what they lacked. Newcastle have no player of the inventiveness of Julian Brandt, no specialist in picking the lock. Their system contains no space for a No 10; their squad has no one with that skillset, though Brandt excels playing off the left for Dortmund. Perhaps European football necessitates more of an artist; maybe a future spending spree should be focused around someone with those qualities. That lack of a genuine creator in the final third is a partial explanation of their inability to score in three of four Champions League games. Some of the goals they did score in the other - Burn’s magnificent header, Fabian Schar’s long-range strike – were the most special because they had the feel of one-offs. In contrast, Nick Pope’s heroics have come to seem the norm. The goalkeeper has been Newcastle’s finest player in three of their other supposed elite players were out of sorts, on the bench or absent altogether, it wasn’t enough. Maybe Newcastle’s efforts won’t be, either: and if this is a learning curve, a lesson may be that overachieving in England is one thing. Doing it in Europe is altogether harder. Read More Outclassed Newcastle left on the brink of anticlimactic Champions League exit What do Arsenal, Man City, Man United and Newcastle need to reach last UCL 16? Borussia Dortmund v Newcastle LIVE: Champions League result and reaction Lascelles hits out at Jorginho after Arsenal star snubs handshake Arsenal decry ‘unacceptable refereeing and VAR errors’ after Arteta outburst How Anthony Gordon became central to Newcastle’s Champions League hopes

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Synthetic viruses could be generated through the misuse of artificial intelligence and potentially spark pandemics, a former Google executive and AI expert has warned. Google DeepMind co-founder Mustafa Suleyman expressed concern that the use of AI to engineer pathogens to cause more harm may lead to a scenario like a pandemic. “The darkest scenario is that people will experiment with pathogens, engineered synthetic pathogens that might end up accidentally or intentionally being more transmissible or more lethal,” he said in a recent episode of a podcast. Similar to how there are restrictions in place to prevent people from easily accessing pathogenic microbes like anthrax, Mr Suleyman has called for the means to restrict access to advanced AI technology and software that runs such models. “That’s where we need containment. We have to limit access to the tools and the know-how to carry out that kind of experimentation,” he said in The Diary of a CEO podcast. “We can’t let just anyone have access to them. We need to limit who can use the AI software, the cloud systems, and even some of the biological material,” the Google DeepMind co-founder said. “And of course on the biology side it means restricting access to some of the substances,” he said, adding that AI development needs to be approached with a “precautionary principle”. Mr Suleyman’s statements echo concerns raised in a recent study that even undergraduates with no relevant background in biology can detail suggestions for bio-weapons from AI systems. Researchers, including those from the Massachusetts Institute of Technology, found chatbots can suggest “four potential pandemic pathogens” within an hour and explain how they can be generated from synthetic DNA. The research found chatbots also “supplied the names of DNA synthesis companies unlikely to screen orders, identified detailed protocols and how to troubleshoot them, and recommended that anyone lacking the skills to perform reverse genetics engage a core facility or contract research organization”. Such large language models (LLMs), like ChatGPT, “will make pandemic-class agents widely accessible as soon as they are credibly identified, even to people with little or no laboratory training,” the study said. The study, whose authors included MIT bio risk expert Kevin Esvelt, called for “non-proliferation measures”. Such measures could include “pre-release evaluations of LLMs by third parties, curating training datasets to remove harmful concepts, and verifiably screening all DNA generated by synthesis providers or used by contract research organizations and robotic ‘cloud laboratories’ to engineer organisms or viruses”. Read More China’s ‘government-approved’ AI chatbot says Taiwan invasion is likely Government urged to address AI ‘risks’ to avoid ‘spooking’ public Scientists give verdict on Harvard professor’s claim of finding materials in sea from outside Solar System Google boss says he wants to make people ‘shrug’ Why is Elon Musk obsessed with the letter X? Elon Musk ‘borrowed $1bn from SpaceX’ at same time as Twitter acquisition

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