The disconsolate trudge is becoming a disconcertingly familiar sight. Kevin De Bruyne has limped out of grander games than the curtain raiser to a Premier League. He has made an early exit from bigger occasions this summer. His Champions League final, like his evening in Burnley, came to a premature conclusion. A focus on De Bruyne’s body can concentrate on the remarkable right foot he uses to unlock defences, to pass and cross with an ability most can only envy. It may switch to his increasingly fragile hamstrings. For De Bruyne, Inter Milan may be bracketed alongside Burnley in the memory. His last two starts, two months apart, ended with him hamstrung. “He was injured again, unfortunately. A problem in the same position, he said to me as in the final of the Champions League,” rued Pep Guardiola. “It depends on the magnitude of the injury but it will be a few weeks out.” There will be no De Bruyne against Sevilla in the European Super Cup or against Newcastle in the first major test of Manchester City’s defence of their Premier League title. He could sit out the start of their Champions League campaign. A summer sandwiched by injuries suggests De Bruyne was rushed back. He had said after the Community Shield he was way ahead of schedule; he had targeted the Super Cup for his comeback. “It’s a pity because he had recovered well,” Guardiola said. “Maybe it was my mistake [to pick him] but if he is injured after 15-20 minutes it is not something wrong, when it is 65 or 70 it is the fatigue of the muscle. We have to talk with the doctors and him.” His plan, he had said, was to give the Belgian 50 or 55 minutes, rather than the cameo he had at Wembley. Which, as that culminated in the penalty he slammed against the underside of the bar in the shootout, has completed an ill-fated start to the season. “He is disappointed but he is strong and will be back,” added Guardiola. Yet for how long? De Bruyne may be increasingly injury prone. For a player who has never looked like a natural athlete, a red-faced figure who can seem a throwback to earlier eras, he has shown great durability. He has won 99 caps for Belgium – he would have brought up a century in the summer but for injury – and this was the 587th game of his club career. His 32nd birthday only came in June but to play almost 700 matches by that stage means he has plenty of miles on the clock. Or miles on the hamstring. He revealed after the Champions League final he had played for two months with the risk it could snap. By the time he is fit again, he will have spent the vast majority of six months with a hamstring problem of some description. It has prompted fears it will be a constant for the rest of his career. A reunion with City’s other talismanic Belgian could illustrate it. Vincent Kompany, a colleague for club and country, still made huge contributions in the latter years of his time at the Etihad Stadium but did not make 30 appearances in any of the last four campaigns. He played his final game at 33. De Bruyne should show greater longevity but his appearances will have to be rationed. All of which could create a problem, even in a squad as gifted as City’s. De Bruyne is a unique talent – “what a player he is,” gushed Kompany – and, as his total of 29 assists last season shows, reaches extraordinary levels of creativity. He is Erling Haaland’s supplier-in-chief and the shifting dynamics in the City squad has rendered his qualities perhaps still more significant. The departures of Riyad Mahrez and Ilkay Gundogan have stripped them of two of the likeliest providers of goals and assists amid the band of attacking midfielders and wingers. Mateo Kovacic won’t deliver as many as the German; should Lucas Paqueta arrive, another able technician won’t replicate Mahrez’s contribution in the final third. De Bruyne is irreplaceable in various respects: no one is a like-for-like alternative and, as he ventures further into his thirties, City will have to ponder the question of who his long-term successor is. In the short term, they can console themselves with memories of Phil Foden’s impact when he came on for De Bruyne in the Champions League final and that, when he was sidelined for much of the 2018-19 campaign, they did a domestic treble. But now each injury comes with the sense that it will not be the last, but that De Bruyne is nearer the end. A man who has illuminated many a game may miss more and more. Read More Kevin De Bruyne faces ‘a few weeks out’ after suffering another hamstring injury Pep Guardiola reveals extent of Kevin De Bruyne’s hamstring injury Erling Haaland at the double as Manchester City kick off new campaign in style

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Smoking causes 150 cancer cases every day in the UK alone, according to a new study. While tobacco smoking in the UK and US peaked to about 50 per cent in the 1950s, this had dropped to around 13 per cent in 2020-21 due to control efforts, said the study. However, historically high smoking rates are still a driving factor of the cancer burden in the countries today, it said. Very high-income countries like the UK are projected to see a 50 per cent increase in cancer cases over the next 50 years, said Cancer Research UK, that funded the study, on Wednesday. Researchers called on MPs to support raising the age of sale of tobacco products as a critical step to create the first ever smoke-free generation. “Action on tobacco would have the biggest impact – smoking causes 150 cases of cancer in the UK every single day,” said Ian Walker, executive director of policy and information at Cancer Research UK. “There are cost-effective tools at hand to prevent cases of cancer, which will save lives around the world. “Tobacco control measures are chronically underfunded. And as a recognised leader in global health, the UK government can play a significant role in addressing this,” Mr Walker said. The study also revealed at least 1.3 million people in seven countries die due to cancer caused by smoking tobacco. The deaths across the UK, US, Brazil, Russia, India, China and South Africa represent over half the world’s annual cancer death burden. The study analysed the years of life that were wasted to cancer. It also assessed whether certain risk factors caused deaths more prematurely. Researchers found four preventable risk factors resulted in almost two million deaths combined and over 30 million years of life lost each year. These factors are smoking, alcohol consumption, obesity and human papillomavirus (HPV) infections. At least 20.8 million years of life are lost from smoking tobacco alone, found the study. It also warned new cancer cases could surge by five times, from 0.6 million to 3.1 million per year in low-income countries over the next 50 years. “These numbers are staggering, and show that with action on a global scale, millions of lives could be saved from preventable cancers,” Mr Walker said. Researchers also found gender differences in the number of cancer deaths. Men were observed to have higher rates of years of life lost to smoking and drinking alcohol as these rates tend to be higher in men. In China, India and Russia, the rates of years of life lost to tobacco smoking and alcohol were up to nine times higher in men than women, found the study. The research was published in the journal eClinicalMedicine and involved the work of researchers from King’s College London and Queen Mary University of London. Read More Binman shoots first Hollywood film after chat with Mark Wahlberg changed his life UK’s tallest living Christmas tree lit up with 1,800 bulbs Morrisons Christmas ad features iconic 80s track and shares support for festive hosts The best foods to forage in November and how to cook them Millions of women able to get contraceptive pills over the counter next year Woman with cystic fibrosis had weeks to live – now she’s climbing mountains

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