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Anthos Therapeutics' Novel Dual-Acting Factor XI/XIa Inhibitor, Abelacimab 150 mg, Demonstrated a 67% Reduction in the Primary Endpoint of Major or Clinically Relevant Non-Major Bleeding Compared with Rivaroxaban in Patients with Atrial Fibrillation
Anthos Therapeutics' Novel Dual-Acting Factor XI/XIa Inhibitor, Abelacimab 150 mg, Demonstrated a 67% Reduction in the Primary Endpoint of Major or Clinically Relevant Non-Major Bleeding Compared with Rivaroxaban in Patients with Atrial Fibrillation
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Nov 12, 2023--
2023-11-12 21:57
'We need him' - Croatia coach asks Modric to postpone retirement
'We need him' - Croatia coach asks Modric to postpone retirement
Croatia coach Zlatko Dalic on Monday appealed to star midfielder Luka Modric to stay amid growing speculation the captain will...
2023-06-19 21:59
Young Lions go goal crazy as they put nine past Serbia in qualifier
Young Lions go goal crazy as they put nine past Serbia in qualifier
England Under-21s went goal crazy as they produced a stunning display to crush Serbia 9-1. Chelsea forward Noni Madueke, debutant Jaden Philogene and Harvey Elliott all scored twice at the City Ground. Liam Delap, Jonathan Rowe and Luka Subotic’s own goal heaped further misery on Serbia as the Young Lions came from behind in their first home game since winning Euro 2023. They had to hit back, despite dominating, after Vladimir Lucic’s classy strike gave Serbia the lead in the Euro 2025 qualifier. Victory made it two from two in Group F ahead of Monday’s game with Ukraine in Slovakia. Boss Lee Carsley had moved to distance this squad as European champions with just six of his winners featuring on Thursday after the majority of the class of 2023 aged out. His new-look Young Lions should have been cruising inside 10 minutes but Charlie Cresswell planted a free header wide after Philogene’s effort was turned over by Veljko Ilic. The goalkeeper then gathered a tame effort from Elliott and continued to deny the hosts, a reaction stop keeping out Philogene at the far post. Madueke pulled the strings, the forward teasing the overworked Serbia defence, but he should have done better than to drag wide following a neat exchange with Hayden Hackney. Carsley’s side dominated, Elliott shooting over, but they were shocked by Serbia after 27 minutes. Lucic started the move on the left and when Nikola Stankovic was played in behind Hackney he found Lucic to brilliantly guide a first-time finish into the top corner from 16 yards. It was a stunning finish and checked England’s momentum which, until then, had only been growing. The Young Lions were briefly cautious as they sized their opponents up again but Delap should have levelled nine minutes before the break rather than let Ilic save with his legs. Yet just two minutes later they levelled as Philogene marked his debut by smashing in high from the edge of the box after being gifted the ball by Ilic. Elliott went close before England got the second they deserved after 41 minutes when captain Cole Palmer was thwarted by Ilic but Philogene recycled the ball to find Delap who crashed in from five yards. It opened the floodgates and Elliott added a third when he collected the ball, advanced and arrowed a strike into the top corner. Eight minutes after the break Madueke got the goal he deserved when he danced across the Serbia defence and drilled in low. It was now a procession, with Serbia resorting to needless fouls to halt England’s rhythm, but they could do nothing to stop Madueke’s second. Hackney was allowed to run and slip the ball into Rico Lewis whose backheel found Madueke to roll into the corner. England continued to pile on the pain and Philogene got his second after 63 minutes, Delap unselfishly squaring to his Hull team-mate after Lewis put him clear. The scoreline reflected the gulf in quality and Cresswell and James McAtee went close to adding a seventh before Elliott hit the crossbar. It was left to Serbia to embarrass themselves as, under pressure from Jamie Bynoe-Gittens, Mitar Ergelas’ clearance clattered off Subotic and looped over Ilic with three minutes left. There was still time for substitute Rowe to get a debut goal, the Norwich forward heading in Elliott’s cross from close range. Then, in stoppage time, Elliott added the flourish with a ninth goal, seizing on Igor Miladinovic’s wretched pass to complete the scoring. Read More Marcus Smith set for full-back role in England’s World Cup quarter-final Scotland slip to defeat in Spain but qualification hopes remain alive FA would face criticism one way or another for conflict response – Southgate Southgate says experimental England must have right mindset against Australia Graham Arnold urging Australia to claim England scalp for ‘kids and nation’ England ready for challenge of knocking India ‘off their perch’ – Chris Woakes
2023-10-13 05:26
Snoop Dogg reveals the one person who can out-smoke him in resurfaced clip
Snoop Dogg reveals the one person who can out-smoke him in resurfaced clip
Snoop Dogg recently announced his decision to quit smoking and since then a clip has resurfaced where the rapper revealed the 'only person' who can out-smoke him. The 52-year-old - whose real name is Calvin Cordozar Broadus Jr - took to Instagram yesterday (November 16) to share the news with fans. "After much consideration and conversation with my family, I've decided to give up smoke. Please respect my privacy at this time," he wrote. The announcement surprised fans, given Snoop's well-documented love for weed and the responses ranged from wishing him well to questioning whether it was some kind of publicity stunt. Meanwhile, a clip from 2018 when Snoop appeared as a guest on Jimmy Kimmel Live! has been making rounds, where he revealed the only person - a musician - that could out-smoke him. The conversation began with Kimmel asking Snoop who he would put on a ‘Mount Rushmore' of pot smokers. "Seth Rogen was here last week, and we were talking about Mount Rushmore of pot smokers, and of course, you are on. "And I think that Seth is on Mt. Rushmore. Who would you put on that Mt. Rushmore?" Kimmel put to the Drop It Like It's Hot rapper. Snoop pondered for a moment before he gave his answer: "I would put Bob Marley." “I would put Cheech and Chong - they were the first faces on the mountain, they're the ones who showed us what a mountain was." "Willie P. Nelson is definitely on there," he added. "And by the way, Willie Nelson is the only person who has ever out smoked Snoop Dogg. I had to hit the 'time out' button." When questioned by Kimmel as to whether he's had to hit the 'time out' button before, Snoop insisted: “Never, never.” Nelson has also recalled the time he spent with Snoop, as he told the Daily Beast in 2021 how they connected when they were both in The Netherlands. “That was over in Amsterdam!" the country musician said, a city where smoking marijuana in coffee shops is accepted. “I called Snoop and I said, 'Hey buddy, you gotta come over here. This is where it’s at!' "So, he came over and we hit every bar, every smoke place in Amsterdam. We had a helluva time." How to join the indy100's free WhatsApp channel Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.
2023-11-18 02:27
Money-saving chilli con carne that absolutely slaps with flavour
Money-saving chilli con carne that absolutely slaps with flavour
This is a versatile dish that you can pair with many different things; have it with rice, smother it over fries, put it on a hot dog, pour it over a jacket spud or just use it as a dip for tortilla chips,” says Mitch Lane, author of Feed Your Family For Under A Fiver. “It can be frozen as well, so it’s great for saving time while meal prepping! I use store-bought chilli con carne seasoning, but if you have a lot of spices in your cupboard (cumin, chilli powder, paprika, cumin seeds) then you’re on to a winner. This is so simple and it absolutely slaps with flavour.” Chilli con carne Serves: 4 Ingredients: 1 tsp vegetable or olive oil 1 onion, finely chopped 4 garlic cloves, finely chopped 2 green chillies, finely chopped, plus 1 to serve 500g minced beef 41g packet of chilli con carne seasoning 400g tin chopped tomatoes 130g tin kidney beans, drained 300ml beef stock (made with a stock cube) Salt and pepper Method: 1. Put a pan on a medium heat and add the oil and the onion and soften for three to four minutes. Add the garlic and chillies and continue to cook for a further two minutes. If you’re not keen on a lot of spice just use one chilli and remove the seeds. 2. Add the mince and break it up with the back of a spoon, ensuring that there’s no big lumps. Cook the meat until it’s nice and brown. Be generous with the salt and pepper and then add the chilli con carne seasoning. Mix well. 3. Add the tomatoes and kidney beans and stir. Then pour in the beef stock and simmer for 30 minutes. The simmering is very important (it’s like a fine wine that gets better with age). 4. Serve with sliced chilli. ‘Feed Your Family For Under A Fiver’ by Mitch Lane (Thorsons, £16.99). Read More The dish that defines me: Mallini Kannan’s baked honey-soy salmon Breakfast for dinner and four other things you should cook this week How to save money in the kitchen according to top chefs How to pimp up your instant ramen (and save money) Do it for the Gram: Speedy but spectacular goat’s cheese linguine Where to find the best Guinness in London – and how to spot a bad one
2023-08-16 13:58
Five months in with no deal in sight, Israel's judicial protests endure
Five months in with no deal in sight, Israel's judicial protests endure
By Rami Amichay TEL AVIV Amid a sea of hundreds, perhaps thousands of Israeli flags at an anti-government
2023-05-28 03:55
Another key inflation gauge fell sharply in May
Another key inflation gauge fell sharply in May
US inflation at the wholesale level has cooled once again, this time landing below its pre-pandemic average.
2023-06-14 20:50
Silvio Berlusconi obituary: Scandal-ridden Italian billionaire, media mogul and the king of comebacks
Silvio Berlusconi obituary: Scandal-ridden Italian billionaire, media mogul and the king of comebacks
Silvio Berlusconi, the boastful billionaire media mogul who was Italy’s longest-serving premier, despite scandals over his sex-fueled parties and allegations of corruption, has died. A one-time cruise ship crooner, Berlusconi used his television networks and immense wealth to launch his long political career, inspiring both loyalty and loathing. To admirers, the multiple-time premier was a capable and charismatic statesman who sought to elevate Italy on the world stage. To critics, he was a populist who threatened to undermine democracy by wielding political power as a tool to enrich himself and his businesses. Born in 1936 in Milan to a bank clerk father and housewife mother, he attended a Catholic college, the start of a complicated relationship with the church, which supported him until the mounting allegations of sleaze “superceded the limits of decency”, in the view of at least one weekly Catholic newspaper. His capacity to entertain emerged early when he worked on cruise ships and played bass with a band, performing George Gershwin hits like “I Got Rhythm” in the dancehalls of Milan before being sacked for devoting more time to flirting with punters (“marketing and PR”, he called it) than playing music. After graduating in law, Berlusconi turned down a job as a cashier at the bank where his father had worked in order to strike out as a property developer. His ambition was notable. To pull off an early make-or-break deal, he persuaded a secretary to tell him when her pension fund director boss would be taking a seven-hour train journey so as to ensure he could secure the seat next to him. Later, when the flight path put off buyers over his Milano 2 residential development, he had alternative routes opened. A modest plan to make his homes more attractive by offering a local cable TV service, Telemilano, which showed light entertainment and reruns of American soap operas such as Dallas, grew into a network of local channels until, by the end of the 1980s, his trash TV empire of game shows and barely-clothed hostesses came to dominate Italian airwaves. As well as hauling in advertising revenue, Berlusconi’s channels allowed him to give favourable coverage towards friendly politicians who helped him protect his commercial interests, which now included publishing houses and the football team AC Milan. When he entered politics himself, these contacts would prove indispensable. The Clean Hands corruption probes that took out a generation of Italian politicians eventually provided the motivation for that move. Power, he reasoned, would not only protect himself from prosecutors but allow him to defend his businesses. Headline-grabbing proposals included a million new jobs and lower taxes. A political outsider positioned as an enemy of the establishment, Berlusconi was in many ways a prototype for Donald Trump. Running a successful Serie A side like the “rossoneri” was one of his main qualifications for high office, he felt. When challenged by an economist over his tax plans, he replied: “How many intercontinental [football cups] have you won?” In 1994, he took 21 per cent of the vote in the general election and found himself prime minister, beginning a two decade-long domination of Italian politics through which he shamelessly advanced his own interests. His personal lawyers, now on the state payroll as MPs, spent their time drawing up laws to get him out of trouble, including immunity from prosecution for the prime minister and a tax amnesty that saved his company 120m euros. His communication minister meanwhile amended competition rules allowing him to retain his media empire. His calling to international relations was evident when he made himself foreign minister as well as prime minister, wooing foreign leaders such as Tony Blair and Putin by inviting them to his James Bond-esque Sardinian villa, complete with fake volcano. Cherie Blair described her evening there as the best of her life. But gaffes such as calling America’s first black president Barack Obama “suntanned” and suggesting a German MEP should play a concentration camp guard made him an international laughing stock. His standing took a further hit in 2009 when his second wife, Veronica Lario, publicly accused him of “frequenting minors”. When a 17-year-old Moroccan nightclub dancer, known as Ruby-the-Heartstealer, who was arrested for a petty crime, told police she knew Berlusconi, the claim set in motion a chain of events that would bring about the mogul’s downfall. Ironically, if Berlusconi had not interceded claiming she was the niece of Hosni Mubarak, the Egyptian despot, the case might have ended there. Investigators, their hackles raised by Berlusconi’s meddling, discovered that a harem of showgirls and models regularly visited his villas for sex parties where they received lavish gifts and envelopes of cash. The drip-feed of salacious details appalled even Italy, where mistresses are less taboo for rich men. Thousands took to the streets in protests that expressed women’s frustration at their humiliating role in Berlusconi’s Italy. But, ultimately, it was not the “bunga bunga” parties that undid him, but his inability to cope as Italy’s debt reached unsustainable levels in 2011 and he was forced to resign in favour of technocrats. Out of office, he remained in the spotlight, thanks to his own media empire and as the defendant in dozens of trials, throughout which he claimed he was the victim of a plot by a left-wing judiciary. After years when, Teflon-like, he had wriggled out of every writ, his eventual conviction for tax fraud in 2014 and subsequent sentencing to community service in a home for Alzheimer’s sufferers represented rock bottom, but, as usual, Berlusconi proved irrepressible, entertaining residents with bingo games and singalongs - a revival of his old cruise ship act. His final years went some way towards rehabilitating his image. He became the oldest member of the European Parliament, his centrist pro-European politics far preferable, in the eyes of German chancelleor Angela Merkel, to the dangerous populist ideals that surged in Europe. When, in February 2021, his party joined a government led by that most establishment of figures, former European Central Bank chief Mario Draghi, his triumphant comeback was complete. His return to government represented an unlikely final twist in the story of a figure who had risen from selling electric hairbrushes to being the richest and most powerful man in Italy and the object of global fascination as (depending on your point of view): a media mogul, marketing genius, football club owner, political trailblazer, womaniser and showman. For every Italian that hated him for his monopolistic control of the media and abuse of power, there was another who admired his business acumen and was amused by his lowbrow larks. As the writer Curzio Malaparte wrote, Berlusconi’s qualities and defects “are the qualities and defects of all Italians”. Berlusconi is survived by 12 grandchildren and five children: Pier Silvio, Marina, Barbara, Eleonora and Pierluigi. Read More Perhaps the most surprising part of the Italian crisis is that Berlusconi has emerged as a selfless voice of reason Italy’s comeback kid: How Silvio Berlusconi has managed to re-enter politics, despite all the scandals Silvio Berlusconi tells female reporter her handshake is so strong 'no one will want to marry her' Silvio Berlusconi dead: Billionaire former Italian prime minister dies aged 86
2023-06-12 17:15
Manchester United fans head to Old Trafford to pay tribute to Sir Bobby Charlton
Manchester United fans head to Old Trafford to pay tribute to Sir Bobby Charlton
Manchester United fans have flocked to Old Trafford to pay tribute to Sir Bobby Charlton following his death aged 86. A book of condolence was opened at 10am on Sunday in the International Suite and supporters laid flowers and scarves and left messages for one of their most famous sons. One read: “Thank you Sir Bobby, a hero to the worldwide football family,” while a message from fan group The 1958 said: “History, dignity and integrity is what you gave to our great club. Our promise to you is to make sure it stays.” Charlton was a key member of England’s victorious 1966 World Cup team and also enjoyed great success at club level with United, who became the first English club to win the European Cup in 1968. His family announced on Saturday afternoon that he had died peacefully in the early hours of the morning surrounded by his family. United led the tributes, saying in a statement: “Manchester United are in mourning following the passing of Sir Bobby Charlton, one of the greatest and most beloved players in the history of our club. “Sir Bobby was a hero to millions, not just in Manchester, or the United Kingdom, but wherever football is played around the world. “He was admired as much for his sportsmanship and integrity as he was for his outstanding qualities as a footballer; Sir Bobby will always be remembered as a giant of the game.” Charlton made his debut for United in 1956 and went on to play 758 matches for the Red Devils, scoring 249 goals. Both were long-standing club records until they were overtaken by Ryan Giggs and Wayne Rooney, respectively. Manchester United are in mourning following the passing of Sir Bobby Charlton, one of the greatest and most beloved players in the history of our club Manchester United statement Charlton won three league three titles and one FA Cup at Old Trafford and, after leaving United in 1973 and becoming Preston manager, he returned to Old Trafford 11 years later as a club director. He was knighted for services to football in 1994. The statement continued: “His unparalleled record of achievement, character and service will be forever etched in the history of Manchester United and English football; and his legacy will live on through the life-changing work of the Sir Bobby Charlton Foundation. “The club’s heartfelt sympathies are with his wife Lady Norma, his daughters and grandchildren, and all who loved him.” United manager Erik ten Hag described Charlton as “a legend” and “a giant” as he paid his own tribute after his side’s 2-1 win at Sheffield United on Saturday night. A wreath was put in the centre circle as a minute’s applause was held before kick-off, while another wreath was laid at the base of the statue of Charlton, George Best and Denis Law in front of Old Trafford. “His achievements are so immense and huge – global, not only England,” Ten Hag said. “You see the facts he achieved are incredible. All the games, his titles, his trophies, the contribution he had with his goals. “I never had the honour to meet him, but I heard, despite all his trophies and games, he was so humble. A big personality and an example for all of us as a footballer and also in society.” Charlton’s European Cup success at United came 10 years after the Munich air disaster, which he and team manager Sir Matt Busby survived but which claimed the lives of eight of Charlton’s team-mates. Born in Ashington on October 11 1937, Charlton played in the World Cup final alongside his brother Jack, who died aged 85 in 2020, and won 106 caps for England, scoring 49 goals. Charlton was diagnosed with dementia and the announcement of his condition made public in November 2020, two days after his United and England team-mate Nobby Stiles died following his own battle with the illness. The official England account on X, formerly known as Twitter, wrote: “It is with a heavy heart that we have learned of the passing of Sir Bobby Charlton. “An integral part of our 1966 FIFA World Cup winning campaign, Sir Bobby won 106 caps and scored 49 times for the #ThreeLions. “A true legend of our game. We will never forget you, Sir Bobby.” Prince William, president of the Football Association, paid tribute to Charlton on social media. Writing on the official account of The Prince and Princess of Wales, William said: “Sir Bobby Charlton. First Division Champion. European Champion. World Champion. Gentleman. Legend. A true great who will be remembered forever. Thank you Sir Bobby. W.” England manager Gareth Southgate added: “One of our most iconic players, Sir Bobby Charlton’s impact on our only World Cup triumph is there for all to see. “The privilege of meeting him on several occasions allowed me to understand his personal pride and emotion in having represented England and simply confirmed in my mind his standing as one of the gentlemen of the game. “The world of football will unite in its sadness at losing an undisputed legend.” A tribute to Charlton was shown on giant screens outside Wembley on Saturday night, while England will pay a full tribute at the European Championship qualifier against Malta at Wembley on November 17. Charlton made his England debut against Scotland at Hampden Park in April 1958, just over two months after he had survived the Munich air disaster. He was not selected for England’s 1958 World Cup squad that summer, but played at the tournament in 1962, 1966 and 1970. Charlton scored three times at the 1966 World Cup, including both goals in the 2-1 semi-final victory over Portugal, and ended his England career at the age of 32 following the quarter-final exit to West Germany in 1970. Wayne Rooney broke Charlton’s scoring records for both Manchester United and England and heard the news during the Sky Bet Championship match between Middlesbrough and Birmingham at the Riverside. Birmingham boss Rooney said: “As I came out for the second half, I didn’t know what was happening. I see his image on the big screen and it hit me what had happened. “Bobby was always great with me, we had many conversations about football and life. He is a huge inspiration not just to me but to a lot of players who have played for Manchester United. “He was the first to congratulate me when I broke the record at Stoke. He came in after the game with his wife. He said congratulations – and a few more harsh words, jokingly. “He was a top human being, which is more important.” Middlesbrough manager Michael Carrick, another former United player, said: “One particular memory that stands out was the 50-year anniversary of Munich. “He came into the training ground and spoke to us about the tragedy and what it meant to him. That’s 45 minutes that I will never, ever forget.” Charlton’s death means Sir Geoff Hurst is the only survivor from England’s 1966 World Cup final win over West Germany. Hurst, who hit a hat-trick in the 4-2 Wembley victory, said: “Very sad news today 1 of the true Greats Sir Bobby Charlton has passed away. We will never forget him & nor will all of football. “A great colleague & friend he will be sorely missed by all of the country beyond sport alone. Condolences to his family & friends from Geoff and Judith.” England’s current record goalscorer, Harry Kane, told Sky Sports: “It’s a sad day for English football for sure. I send my love and condolences to his friends and family. “Sir Bobby was one of England’s greatest ever players, if not the greatest. I’m proud that I was able to meet him. “Obviously he was a big supporter of the national team, watching us whenever he could. A sad day but what a fantastic person, what a fantastic life he lived.” Writing on Instagram following United’s win over Sheffield United, forward Marcus Rashford said: “I signed my first professional contract at Man Utd with Sir Bobby. “Thank you for all the support and advice that you provided to me. That win was for you and your family.” Read More South Africa investigating alleged racist abuse directed at England’s Tom Curry Jack Catterall likely to face Josh Taylor rematch in Glasgow or Manchester Jeremy Doku says Manchester City need to keep proving they are the ‘best team’ Newcastle boss Eddie Howe praises ‘ultimate professional’ Jacob Murphy Erik ten Hag says Harry Maguire ‘playing like we want him to’ Ange Postecoglou praises ‘professional’ Pierre-Emile Hojbjerg
2023-10-22 20:17
FBI misused intelligence database in 278,000 searches, court says
FBI misused intelligence database in 278,000 searches, court says
By Zeba Siddiqui SAN FRANCISCO A U.S. court found that the FBI improperly searched for information in a
2023-05-20 06:47
Mavericks spoil Victor Wembanyama's NBA debut, beat the Spurs 126-119 in the teams' opener
Mavericks spoil Victor Wembanyama's NBA debut, beat the Spurs 126-119 in the teams' opener
Luka Doncic had 33 points, 14 rebounds and 10 assists and the Dallas Mavericks spoiled the NBA debut of No. 1 draft pick Victor Wembanyama, beating the San Antonio Spurs 126-119
2023-10-26 12:53
Macau facing increased restrictions under expanded security law
Macau facing increased restrictions under expanded security law
The government in the Chinese territory says the changes are in line with legislation in Hong Kong.
2023-05-31 04:54