Centenarians tend to have lower levels of glucose, creatinine and uric acid from their sixties onwards, according to the largest study of its kind that may lead to a simple blood test to predict a person’s chance of reaching 100. The research, published on Monday in the journal GeroScience, is the biggest to date to measure and follow up the levels of different molecules in the blood of people born between 1893 and 1920. Scientists, including those from Karolinska Institutet, assessed the data on blood molecules from over 44,500 Swedes who underwent clinical testing between 1985 and 1996 and followed up till 2020. They focused specifically on people born between 1893 and 1920, who were between 64 and 99 years old when their blood samples were first tested, and followed them up as they grew closer to 100 years of age. About 1,200 individuals in the study, or about 2.7 per cent of the participants, reached 100. Researchers compared this subset’s data with those of their peers who were younger than them. The analysis found 12 blood-based molecules associated with metabolism, inflammation as well as liver and kidney function, that were also linked to ageing or mortality in previous studies. These molecules included total cholesterol and glucose as markers of metabolism, uric acid indicating inflammation levels, enzymes indicative of liver health and creatinine as a measure of kidney health. Researchers also looked at albumin and iron levels in the blood. Except for a liver enzyme and albumin, all other molecules were found linked to the likelihood of a person becoming a centenarian. Those with increased levels of total cholesterol and iron had a greater likelihood of becoming centenarians compared to those with lower levels. However, for molecules including glucose, creatinine, uric acid, and liver enzymes, lower levels were associated with higher chances of living past 100. “We found that, on the whole, those who made it to their hundredth birthday tended to have lower levels of glucose, creatinine and uric acid from their sixties onwards,” researchers wrote in The Conversation. “Very few of the centenarians had a glucose level above 6.5 earlier in life, or a creatinine level above 125,” they said. While the differences found in the study between groups were small in some cases, researchers said the findings still suggest a “potential link” between metabolism, nutrition and longevity. However, the study falls short of recommending lifestyle factors or genes responsible for these blood molecule levels. “While chance likely plays a role for reaching age 100, the differences in biomarker values more than one decade prior death suggest that genetic and/or lifestyle factors, reflected in these biomarker levels may also play a role for exceptional longevity,” scientists wrote in the study. “However, it is reasonable to think that factors such as nutrition and alcohol intake play a role. Keeping track of your kidney and liver values, as well as glucose and uric acid as you get older, is probably not a bad idea,” they said. Read More Good financial planning could increase life expectancy, study suggests Scientists find gene that grants long life – and successfully test it on another species Scientists extend mice lives by connecting their blood to young ones

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Joao Felix is heading back to Atletico Madrid with Chelsea choosing not to retain the Portugal winger following his loan deal, according to the Spanish club’s president Enrique Cerezo. Felix, 23, joined Chelsea on loan in January for the remainder of the 2022-23 campaign and went on to score four goals in 20 appearances for the Blues. On Monday, after a difficult campaign in which they finished a lowly 12th in the Premier League, Chelsea announced the appointment of Mauricio Pochettino as their new head coach. And, as reported by Marca, Cerezo said of Felix: “The truth is that I can’t tell you the plan with Joao. “It’s the news we had yesterday, that the new coach doesn’t have him for Chelsea. We don’t have anything planned yet, Joao is an Atletico player now.” Atletico paid £113million to sign Felix, who is under contract with them until 2027, from Benfica in 2019. He has made 131 appearances for Diego Simeone’s side, scoring 34 goals, and helped them win the 2020-21 LaLiga title. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live

When the Dutch Grand Prix returned to the Formula 1 calendar in 2021 – after a 36-year absence – organisers could frankly not have foreseen a future more favourable. A Dutch race reincarnated by-and-large due to a Dutch hero, timed exquisitely for his era of ultra-domination. To the extent that, now, anything other than a Max Verstappen triumph come Sunday would be as big a shock as Formula 1 has seen all season. Verstappen-mania in the Netherlands has long been at fever pitch, with the ‘Orange Army’ previously travelling across Europe to support the man born in Belgium but with Holland in his heart. But now Zandvoort, on the coast of the North Sea, sees thousands make the journey from Amsterdam and beyond to revel and rave in this electro-music, orange-clad razzmatazz amid the sand dunes. Verstappen, coasting to a third-straight F1 championship title this season with a 125-point lead with 10 races remaining, is on track to break more ground. Win on Sunday and he will equal Sebastian Vettel’s record of nine consecutive victories from 10 years ago, also set while at Red Bull. On Friday, fresh from a four-week break, he set down an ominous marker by going fastest in first practice – and only marginally sniffed out of first spot in practice two by his friend Lando Norris, a session delayed by a bizarre double-crash involving Oscar Piastri and Daniel Ricciardo. Formula 1’s return in the Netherlands this weekend feels all the more appropriate given the sheer levels Verstappen is reaching this season. The 25-year-old is on track to reach a half-century knock of victories by the time the year is out – he is currently on 45 with 10 to go – and powered by a Red Bull which is the standout car this year, nothing has stopped his ascent to near-perfection. Not even his team-mate Sergio Perez, armed with the same machinery, has proved a match for Verstappen. Since Azerbaijan in April, Verstappen has won eight races on the trot – 10 if you include sprints – and has been repeatedly unfazed on the occasions he has not started on pole, simply picking off his rivals with supreme ease when needed. Saturdays do offer the chasing pack a glimmer of hope, though. If there is any weakness in this Verstappen-Red Bull partnership, it is qualifying. Both Charles Leclerc and Lewis Hamilton have claimed pole position this season, with Fernando Alonso a shave away in Monaco too. For Leclerc though, speaking to the media on Thursday, it mattered not an an iota. In fact, the pessimism made for a grim forecast for all non-Verstappen fans out there: two-and-a-half years of the current trajectory continuing. “They [Red Bull] have a really big margin,” the Ferrari driver said. “It’s going to be very, very difficult to catch them before the change of regulations [in 2026].” Lewis Hamilton was a tad more measured, but remained far from optimistic: “The fact is Red Bull are ahead and they have most likely started development on next year’s car a month before anybody else. It is very, very possible that Charles could be right.” Beyond the expectancy, even inevitability now, of a Verstappen victory on Sunday, there are always potential avenues for something different. Rain is forecast, intermittently, over the next two days which could bring some unpredictability. The last two races in Zandvoort have been close-run affairs, though ultimately Verstappen ended up on top of the podium. A non-Red Bull pole-sitter would certainly make at least the early stages intriguing. But the man who is on track to be one of the Netherlands’ biggest sporting stars ever does not feel any burden. “It doesn’t bring a weight on my shoulders of extra pressure,” he said on Thursday. “"It is just amazing to be here, see all of the fans and drive such an incredible track. “Hopefully it [the race] will continue for a while,” A third championship is simply a matter of when for Verstappen and Red Bull. Mercedes, Ferrari, McLaren and Aston Martin are in their own battle for second-place. The more pertinent question now, for the history-books, is can anybody stop them? And can they really complete an unprecedented perfect season? Read More Oscar Piastri and Daniel Ricciardo crash in Dutch Grand Prix practice Lewis Hamilton gives blunt response to Felipe Massa’s legal action over 2008 F1 title Charles Leclerc gives gloomy prediction on how quick Ferrari will catch Red Bull Oscar Piastri and Daniel Ricciardo crash in Dutch Grand Prix practice F1 Dutch Grand Prix: When is practice on Friday in Zandvoort? F1 Dutch Grand Prix LIVE: Practice updates and times as Formula 1 returns

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