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Investigators are set to widen the search for Madeleine McCann after photos belonging to prime suspect Christian Brueckner revealed ‘clues’. Two other areas surrounding Praia da Luz, where Madeleine disappeared in 2007, could be searched by police, the Sun reported. Investigators made the discovery after looking through more than 8,000 photographs belonging to Brueckner. A source told the Sun: “German officers have gone through more than 8,000 pictures belonging to Christian B. That forensic work led them to Barragem - but there are other places that have come up in the pictures too. “Detectives are seeking to work out where they are and why Christian B was taking pictures of those places.” Last week police searched the remote Barragem do Arade reservoir in the Algarve, Portugal, around 35 miles from where the then-three-year-old went missing. The office of German prosecutor Christian Wolters said investigators were acting in response to “certain tips”. The reservoir is known to have been frequented by the latest suspect in the case Christian Brueckner. According to Portuguese broadcaster SIC, the suspect considered the area his “little slice of paradise”. Read More How Madeleine McCann search at reservoir unfolded – and what police found Sixteen years and countless heartbreaks: Where are Madeleine McCann’s family now? Madeleine McCann case: Timeline of the missing child’s disappearance How much has the Madeleine McCann investigation cost?

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A treatment for acute migraines has been approved for NHS use for the first time, with experts saying the move could be a “step-change” for thousands of people who suffer from the condition. The National Institute for Health and Care Excellence (Nice) said its final draft guidance on Rimegepant “addresses the high unmet need for treatment options for acute migraine”. Rimegepant, also known as Vydura and made by Pfizer, will be available to adults who have tried at least two triptans – medication usually given to tackle headaches or migraines – but found they did not work well enough. It can also be administered to those who are not able to take triptans or have an intolerance, or patients who have tried nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol. Helen Knight, director of medicines evaluation at Nice, said: “Migraine is a condition described in comments to Nice from carers and people with migraine as an invisible disability that affects all aspects of life including work, education, finances, mental health, social activities and family. “Today’s final draft guidance addresses the high unmet need for treatment options for acute migraine, once again demonstrating our ability to ensure clinically and cost-effective medicines are available to those who need them as quickly as possible.” Rimegepant is taken as a wafer, which dissolves under the tongue and works by stopping the release of a protein around the brain called calcitonin gene-related peptide. In July, the medicine was recommended as an option for preventing episodic migraines in adults who have at least four and fewer than 15 attacks per month if “at least” three other treatments have not worked. This is the first and only Nice-recommended medicine that can help alleviate the misery of acute migraines, and may be considered a step-change in treatment Helen Knight, Nice Under the latest guidance, it will also be used to relieve symptoms of a migraine, which can include pain, nausea and sensitivity to light, but also painless symptoms such as temporary visual disturbances known as “aura”, which Nice said “is not well managed with existing treatments”. The recommendation is expected to benefit about 13,000 people. Ms Knight added: “This is the first and only Nice-recommended medicine that can help alleviate the misery of acute migraines, and may be considered a step-change in treatment.” Migraine is an incredibly misunderstood condition that can have a significant impact on all areas of life, including ability to work, maintain relationships and mental health Robert Music, The Migraine Trust Robert Music, chief executive of The Migraine Trust, said the Nice guidance “provides people with migraine valuable options to help reduce the pain and length of a migraine attack”. “It brings new hope,” he added. “It will especially benefit those who have not found a treatment that works, those who get debilitating side effects – including medicine overuse headache – from them, and those with cardiovascular disease who cannot take existing treatments. “Migraine is an incredibly misunderstood condition that can have a significant impact on all areas of life, including ability to work, maintain relationships and mental health.” Read More NHS winter resilience fund announced by Government NHS reliance on paper notes ‘stopping trusts from realising full potential’ Recession fears as UK economy shrinks by more than expected in shock decline Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live

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Indian Prime Minister Narendra Modi and Chinese leader Xi Jinping agreed to "intensity efforts" to deescalate tensions at their contested border, in a rare face-to-face meeting since a deadly clash strained relations more than three years ago.